[NMusers] Compiler matters for NONMEM installation

Hello nmusers: Some of the most recent versions of compilers have difficulty building NONMEM. Here are some remedies: GNU gfortran 10 and later cannot build NONMEM 7.5.0 or earlier. You must use NONMEM 7.5.1, which has the appropriate syntax change in certain code that the later gfortran does

[NMusers] Sad news about Dr. Ludden

Dear Nmusers: The PK/PD scientists here at ICON express our sincere condolences on the passing of Tom Ludden. As mentioned by several already, Tom was very instrumental in transitioning the NONMEM software development from the labs of Beal, Sheiner, and Boeckmann at UCSF, to Globomax, then to I

[NMusers] testing nmusers, note 1200, please ignore.

Testing nmusers. ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail addr

[NMusers] Testing nmusers system. 1001. Please ignore

Testing nmusers system. 1001. Please ignore. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 731 Arbor way, suite 100 Blue Bell, PA 19422 Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com www.iconplc.com

[NMusers] Testing nmusers. Pleas ignore. No. 1002

Testing nmusers. Please ignore. ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in t

[NMusers] ICON's Online Workshops for PDX-Pop/NONMEM for 2024

Dear Nmusers: The upcoming Online Workshops for PDx-Pop/NONMEM are listed here as follows: Beginners/Intermediate Online NONMEM/PDx-Pop workshop: May 28-29, 2024 Advanced Online NONMEM/PDx-Pop workshop: May 30, 2024 Beginners/Intermediate Online NONMEM/PDx-Pop workshop: Sep 24-25, 2024 Advanced O

[NMusers] books/courses for learning popPK, PK/PD

Hello Gabriella: At ICON we present several online courses, which are scheduled for eastern US time of 9:00-16:00, which would be 15:00-22:00 central Europe time. So no need to travel, if you can handle the mid-afternoon to late evening schdeule. The upcoming Online Workshops for PDx-Pop/NONMEM

[NMusers] NONMEM Error on SAEM but not FOCEI

Clearly a bug in the $ABBR PROTECT processor. The NMTRAN interpreter removes the *EXP(0) (because it does not modify the equation), which messes up $ABBR PROTECT process. This occurs only with EXP(0), but not EXP(1) EXP(2), etc. Work-arounds are: KA = TVKA *EXP(-0) or ZERO=0.0 KA = TVKA *EXP

[NMusers] ICON's Online Workshops for PDX-Pop/NONMEM for January 2024

Dear Nmusers: Information for the January workshops: Beginners/Intermediate Online NONMEM/PDx-Pop workshop: Jan 30,31, 2024 Advanced Online NONMEM/PDx-Pop workshop: Feb 1, 2024 can be found at https://www.iconplc.com/news-events/events/workshops Please e-mail idssoftw...@iconplc.com

[NMusers] ICON's Online Workshops for PDX-Pop/NONMEM for January 2024

Dear Nmusers: Information of the January workshops: Beginners/Intermediate Online NONMEM/PDx-Pop workshop: Jan 30,31, 2024 Advanced Online NONMEM/PDx-Pop workshop: Feb 1, 2024 can be found at https://www.iconplc.com/news-events/events/workshops Please e-mail idssoftw...@iconplc.com

[NMusers] ICON's Online Workshops for PDX-Pop/NONMEM for 2024

Dear Nmusers: The upcoming Online Workshops for PDx-Pop/NONMEM are listed here as follows: Beginners/Intermediate Online NONMEM/PDx-Pop workshop: Jan 30,31, 2024 Advanced Online NONMEM/PDx-Pop workshop: Feb 1, 2024 Beginners/Intermediate Online NONMEM/PDx-Pop workshop: May 28-29, 2024 Advanced On

[NMusers] NONMEM / PDxPoP Workshops Presented by ICON Clinical Research LLC for 2023

Hello everyone: We have the following workshops scheduled for the rest of 2023: 3-day Online Virtual NONMEM/PDxPoP workshops (Days 1 & 2, Day 3) September 26 & 27, September 28 The fee for the virtual

[NMusers] Requesting testing of list serve please ignore

Testing 3456 ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address.

[NMusers] testing nmusers system, please ignore, 1367

Testing nmusers system, please ignore, 1367 ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entit

[NMusers] testing 13345, please ignore

Testing ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If y

[NMusers] Comments by shanpan1...@gmail.com

Dear nmusers: Making a vague, general disparaging statement against a person or institution on a public forum intended for scientific exchange is inappropriate. shanpan1...@gmail.com has been removed from the nmusers list. Robert J. Bauer, Ph.D. Senior Director P

[NMusers] RE:Modeling for non-Normal distributions of individual parameters

6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com> www.iconplc.com<http://www.iconplc.com/> From: Leonid Gibiansky Sent: Tuesday, January 3, 2023 6:47 PM To: Bauer, Robert ; 'nmusers@globomaxnm.com' Subject: [EXTERNAL] Re: [NMuser

[NMusers] Modeling for non-Normal distributions of individual parameters

Dear nmusers: I am providing instructions and examples of how to model individual parameters with gamma distribution among the population in NONMEM. A general method for modeling other distributions is also given. This material is located at (start with the instruction file gamma_indpar.pdf):

[NMusers] 2023 Schedule for Online Workshops Presented by ICON Clinical Research LLC - NONMEM & PDxPoP

Please note the following dates for 2023 for the 3-day online workshops presented by Drs. Robert Bauer and Brian Sadler: January 31-February 2 May 30-June 1 September 26-28 Seating is limited - only 30 participants per course/per day - first come, first served! The cost is $150 per course/per

[NMusers] Condition Number and other matters

Hello Ken: I am quite unaware that some eigenvalues of a properly positive-definite verified variance-covariance from a pure R matrix would be negative, or that this would even occur for its correlation matrix. Similarly, if the variance-covariance form is of sandwich form, such as (Rinv)S(Rinv

[NMusers] Condition number

Hello Ken: I am quite unaware that some eigenvalues of a properly positive-definite verified variance-covariance from a pure R matrix would be negative, or that this would even occur for its correlation matrix. Similarly, if the variance-covariance form is of sandwich form, such as (Rinv)S(Rinv

[NMusers] Condition number

c.com<http://www.iconplc.com/> From: Ken Kowalski Sent: Thursday, December 1, 2022 6:59 AM To: Bauer, Robert ; nmusers@globomaxnm.com Cc: 'Bonate, Peter' Subject: [EXTERNAL] RE: [NMusers] Condition number Hi Bob, Could it possibly be related to the S matrix and the default sandwich estimat

RE: [EXTERNAL] RE: [NMusers] Condition number

c.com/> From: Bill Denney mailto:wden...@humanpredictions.com>> Sent: Wednesday, November 30, 2022 11:31 AM To: Bauer, Robert mailto:robert.ba...@iconplc.com>>; nmusers@globomaxnm.com<mailto:nmusers@globomaxnm.com> Subject: [EXTERNAL] RE: [NMusers] Condition number Hi everyone,

RE: [NMusers] Condition number

Hello all: Report of non-positive definiteness or negative eigenvalues, are reported during the analysis of the R matrix (decomposition and inversion), which occurs before the correlation matrix is constructed.Often, this is caused by numerical imprecision. If the R matrix step fails, the $

[NMusers] Updates Regarding NONMEM 7.5.1 Installer and bug list

Dear nmusers: An updated installer NONMEM751.zip is now available at https://nonmem.iconplc.com/nonmem751 that allows installation of NONMEM 7.5.1 for an aarch64 architecture CPU with Linux operating system. Thanks to Bill Denney for allowing me to create and test the installer on his system.

RE: [EXTERNAL] [NMusers] Continuation of "What does "Second Error signal from LINV1PD: 129"

bert.ba...@iconplc.com> www.iconplc.com<http://www.iconplc.com/> From: Leonid Gibiansky Sent: Friday, September 16, 2022 5:42 PM To: Bauer, Robert ; nmusers Subject: Re: [EXTERNAL] [NMusers] Continuation of "What does "Second Error signal from LINV1PD: 129" Thank you, Bob! Ctl-T com

RE: [EXTERNAL] [NMusers] Continuation of "What does "Second Error signal from LINV1PD: 129"

Leonid: You can enter ctrl-T to see OFV outputs of each subject, and you can note which of the subjects is issuing an LNV1PD: 129 error. The error issues first, then the subject number is shown. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 731 Arbor way, suite 100

RE: [EXTERNAL] Re: [NMusers] Problems when implementing M3 for BLQs

Make sure also that you do not have a data item or variable called PHI. It may interfere with PHI() as a function. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 731 Arbor way, suite 100 Blue Bell, PA 19422 Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@i

RE: [EXTERNAL] [NMusers] MS-MPI

Sam: I do not know. As you are using WFN, you may need to consult Nick Holford, or check up with the MSMPI people about what this error means. I recommend that you use only 8 cpus, and see how that works. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamon

RE: [EXTERNAL] Re: [NMusers] Nonmem 7.5 on MacOS monterey troubleshooting

In a few days, I will be releasing NONMEM 7.5.1, which should be able to be compiled with gfortran/gcc 11 on a MAC with M1 architecture. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile

RE: [EXTERNAL] [NMusers] 173 NUMBER OF PK PARAMETERS EXCEEDS CONSTANT "PG" IN SIZES.

You should specify as $SIZES PG=250 Or whatever size you need. Please see ..\resource\SIZES.f90 for explanations. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 robe

RE: [EXTERNAL] Re: [NMusers] RE: Updated materials on NONMEM 7.5

20878 Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com> www.iconplc.com<http://www.iconplc.com> From: Tingjie Guo mailto:i...@tingjieguo.com>> Sent: Monday, November 1, 2021 10:55 AM To: Bauer, Robert mailto:robert.ba...@iconplc.c

[NMusers] RE: Updated materials on NONMEM 7.5

Dear nmusers: Earlier e-mail contained faulty link to MACOSX. Please use the following links. Please note several updated materials pertaining to the NONMEM software: 1) An updated bug list nm750_bug_list.pdf in In https://nonmem.iconplc.com/nonmem750 2) Updated installer for NONME

[NMusers] Updated materials on NONMEM 7.5

Dear nmusers: Please note several updated materials pertaining to the NONMEM software: 1) An updated bug list nm750_bug_list.pdf in In https://nonmem.iconplc.com/nonmem750 2) Updated installer for NONMEM7.5 for gfortran on Windows. See README_NONMEM750_63gfortran463.txt, utilizing

[NMusers] Director Pharmacometrics US at Astellas we are hiring

Submitted on behalf of Stacey Tannenbaum: Pharmacofriends and colleagues, We are looking for a Director level Pharmacometrician for our team at Astellas.   Come work with me and an amazing group of scientists working on exciting drug development projects We are open to remote work within the c

[NMusers] testing, please ignore #2345

Testing #2345 ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address

[NMusers] nmusers not working properly

Dear nmusers: Several of you have experienced the inability to post messages on nmusers over the past several days. We are presently working on the issue. If you wish to post a message and are experiencing difficulty, please send me your message (to robert.ba...@iconplc.com

[NMusers] Continuous Time Markov Model Data Structure

The following is on behalf of Martin Bergstrand, as there is some difficulty in posting on to nmusers: Dear Ya-Feng, The first data example seems correct but probably requires another record at TIME= 0, to account for what happens before the first observation (e.g. TIME=0 & EVID=2). If you hav

[NMusers] Continuous Time Markov Model Data Structure

The following is on behalf of Martin Bergstrand, as there is some difficulty in posting on to nmusers: Dear Ya-Feng, The first data example seems correct but probably requires another record at TIME= 0, to account for what happens before the first observation (e.g. TIME=0 & EVID=2). If you hav

[NMusers] This is a test for nmusers. Please ignore. 1234

nmusers test, please ignore. ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the

[NMusers] ISOP Webinar, New Features in NONMEM 7.5

Dear nmusers: You are invited to the following webinar: ISoP MCS SIG Webinar Series presents Robert Bauer, Ph.D. Pharmacometrics and PK/PD Modeling & Simulation, ICON Clinical Research, LLC. Seminar Title Understanding the Methodology and Uses of Some New Features in NONMEM 7.5: Clinical Trial

[NMusers] ISOP Webinar, July 14, 2021, 11:00am EDT: Understanding the Methodology and Uses of Some New Features in NONMEM 7.5: Clinical Trial Design Evaluation and Optimization, and Delay Differential

Dear nmusers: You are invited to the following webinar: [https://insp.memberclicks.net/assets/site/New%20Isop%20logo.RS.jpg] ISoP MCS SIG Webinar Series presents Robert Bauer, Ph.D. Pharmacometrics and PK/PD Modeling & Simulation, ICON Clinical Research, LLC. Seminar Title Understanding the

[NMusers] This is a test, please ignore #104557

Testing #104557 Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com www.iconplc.com ICON plc made the following annotations. --

[NMusers] RE: Update installation of NONMEM7.5 on macOS Big Sur with Silicon M1 CPU

fice: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com> www.iconplc.com<http://www.iconplc.com> From: Heine, Rob ter Sent: Thursday, May 6, 2021 9:38 AM To: nmusers@globomaxnm.com; Bauer, Robert Subject: [EXTERNAL] Update installation of NO

RE: [NMusers] Troubleshooting installation of nonmembers 7.5 on Mac with silicon M1 CPU

c.com<http://www.iconplc.com> From: Heine, Rob ter Sent: Wednesday, April 28, 2021 12:52 PM To: Bauer, Robert Cc: nmusers@globomaxnm.com Subject: [EXTERNAL] Re: [NMusers] Troubleshooting installation of nonmembers 7.5 on Mac with silicon M1 CPU Dear Bob, Thanks. I removed the previous non

RE: [NMusers] Troubleshooting installation of nonmembers 7.5 on Mac with silicon M1 CPU

Hello all: Unfortunately the install_Darwin program located at https://nonmem.iconplc.com/nonmem750/MACOSX/

[NMusers] RE: mpiexec exit code 1 even though NONMEM MPI run was successful

Nick: In NONMEM, Exit condition 1 is issued as an identification of a worker, and Exit condition 0 is issued as identification of the (successful) manager. This is in case a user wants a special action taken on manager versus worker. You can create a wrapper script, such as this example, let's

RE: [EXTERNAL] RE: [NMusers] Statistical power computation based on the wald test

onplc.com> www.iconplc.com<http://www.iconplc.com> From: Ken Kowalski Sent: Wednesday, March 24, 2021 1:34 PM To: Bauer, Robert ; nmusers@globomaxnm.com Subject: RE: [EXTERNAL] RE: [NMusers] Statistical power computation based on the wald test Hi Bob, Just a point of clarification. If t

RE: [EXTERNAL] RE: [NMusers] Statistical power computation based on the wald test

Hello all: I would just like to add some information to help the discussion along. In addition to the variance-covariance matrix that is outputted in the .cov file that Ken mentioned, the Fisher information matrix itself (inverse of variance-covariance) is also outputted in the .coi file. Addi

[NMusers] This is a test of nmusers. PLease ignore., #2395

Testing nmusers Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com www.iconplc.com ICON plc made the following annotations. --

RE: [EXTERNAL] [NMusers] A weird problem in $TABLE output when using nonmem 7.4.3 with MPI

Hello Cris: If you add the option -maxlim=3 to your nmfe74 script command line, this will correct the issue. This has been corrected in NONMEM 7.4.4 Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215)

[NMusers] RE: Install problem 7.5.0 on Ubuntu 19.10

Hello nmusers: The installer for Linux was built without the static option, so it requires a shared library. I have rebuilt it statically, and it should no longer require a shared library. Download the new install_Linux from https://nonmem.iconplc.com/nonmem750 to your nm750CD folder Then tr

[NMusers] RE: Install problem 7.5.0 on Ubuntu 19.10

Hello nmusers: The installer for Linux was built without the static option, so it requires a shared library. I have rebuilt it statically, and it should no longer require a shared library. Download the new install_Linux from https://nonmem.iconplc.com/nonmem750 to your nm750CD folder Then tr

RE: [NMusers] ISAMPLE in SAEM algorithm with ETASAMPLES=1

Dear Tingjie: When used in nonmem 7.5, a recommended example/setup would be (as shown on page 152 of nm750.pdf) $SIZES ISAMPLEMAX=250 ... $EST METHOD=SAEM NBURN=500 NITER=1000 MASSRESET=1 ISAMPLE=2 PRINT=20 NOPRIOR=1 RANMETHOD=P $EST METHOD=SAEM NBURN=0 NITER=0 MASSRESET=0 ETASAMPLES=1 ISAMP

RE: [NMusers] ISAMPLE in SAEM algorithm with ETASAMPLES=1

Tingjie: The ETASAMPLES method is better developed in NONMEM 7.5.0, along with the description of it in nm750.pdf Maximal ISAMPLE can be increased with $SIZES ISAMPLEMAX=250 for example. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100

[NMusers] NONMEM 7.5.0 release announcement

Dear NMUSERS: NONMEM 7.5.0 is now available. Please visit the site https://nonmem.iconplc.com/nonmem750 and view readme_750.pdf, nonmem75_features.pdf, and intro7.pdf. These files list new features of NONMEM 7.5.0, bug fixes, and comprehensive installation instructions. The NONMEM7.5.0.zip fi

RE: [NMusers] OFV from different algorithms

It seems there have been two different questions posed on the same subject line. I will deal with each one separately. 1) The original question from Mark Tepeck has been answered by Leonid Gibiansky, that generally when covariate model comparisons are performed, the OFV from the same estimatio

RE: [NMusers] M3 method - WRES, and CWRES

Matt: The NPDE and NPD systems in NONMEM are described in the nm744.pdf manual ( https://nonmem.iconplc.com/nonmem744 ), pages 70-75, and follow along the work of Comet, Brendel, Ngyuen, Mentre, etc. The NPDE R package is not used within NONMEM. Robert J. Bauer, Ph.D. Senior Director Pharmaco

[NMusers] testing nmusers #8910, please ignore.

Testing nmusers. Please ignore. ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in t

[NMusers] testing the nmusers system, test #2345. Please ignore.

Testing please ignore. ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mai

RE: [NMusers] Use AND to ignore rows for input dataset

.com<mailto:robert.ba...@iconplc.com> www.iconplc.com<http://www.iconplc.com/> From: Mark Tepeck Sent: Monday, December 23, 2019 10:50 AM To: Bauer, Robert Cc: Nmusers Subject: Re: [NMusers] Use AND to ignore rows for input dataset Hi Bob, Thank you so much for your feedback. I am so glad to

RE: [NMusers] Use AND to ignore rows for input dataset

rsburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com> www.iconplc.com<http://www.iconplc.com/> From: Mark Tepeck Sent: Tuesday, December 17, 2019 8:21 PM To: Nmusers Cc: Bauer, Robert Subject: Re: [NMusers] Use AND to i

RE: [NMusers] Use AND to ignore rows for input dataset

286-0769 robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com> www.iconplc.com<http://www.iconplc.com/> From: Sebastien Bihorel Sent: Monday, December 16, 2019 5:02 PM To: Bauer, Robert ; Nmusers Subject: Re: [NMusers] Use AND to ignore rows for input dataset Since nowadays most da

RE: [NMusers] Use AND to ignore rows for input dataset

Guide VIII suggests the following: Suppose it is desired that records be dropped that satisfy the logical ".AND." of several conditions. This can be implemented by using an ACCEPT list with the negations of the conditions. For example, suppose that records to be ignored are those having GEN=1 .

RE: [NMusers] FDATA file bug

From: Bauer, Robert Sent: Wednesday, December 11, 2019 9:55 AM To: nmusers@globomaxnm.com Subject: RE: [NMusers] FDATA file bug Mark: While FDATA is designed for NONMEM to read, for the next version, I will have a companion file, FDATA.csv, created if the $DATA CHECKOUT option is specified

[NMusers] FW: Release of NONMEM 7.4.4

Dear NONMEM Customers: A new hot fix release, NONMEM 7.4.4, is now available at: https://nonmem.iconplc.com/nonmem744 (the link might place you at the parent directory, so navigate to nonmem744 if necessary) This release fixes the bugs that were discovered in NONMEM 7.4.3, listed in file nm743

RE: [NMusers] Wrong columns in $TABLE output

Dear nmusers: In response to Tim Waterhouse’s observation, when LVR is set with $SIZES to a value greater than 93, NMTRAN provides the incorrect index numbers to the advanced diagnostic items (CWRES, CPRED, NPDE, etc.) requested by the user on $TABLE. This results in diagnostic items being prin

RE: [NMusers] Wrong columns in $TABLE output

Tim: Best to send me a portion of your data set, and control stream file, see if I can see the cause. Which NONMEM version are you usin? Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile

[NMusers] NONMEM Bibliography

Dear nmusers: A document is now available that lists various tutorial articles and text books pertaining to NONMEM and pharmacometrics. Please link to https://nonmem.iconplc.com/nonmem743/guides and download nonmem_bibliography.pdf. Some of the guides to NONMEM 7.4.3 have also been updated and

RE: [NMusers] Avoid scientific notation in tables

c.com<http://www.iconplc.com/> From: Mark Tepeck [mailto:mark.tep...@gmail.com] Sent: Thursday, June 13, 2019 5:10 PM To: Bauer, Robert Cc: nmusers@globomaxnm.com Subject: Re: [NMusers] Avoid scientific notation in tables Hi Bob, Thank you for your prompt reply. However, I would like to output a CS

RE: [NMusers] Avoid scientific notation in tables

Mark: Yes, you may use the FORTRAN FORMAT specifier such as: $TABLE … FORMAT=sF8.2 available since NONMEM 7.1. Please search for the word FORMAT in the ..\guides\intro7.pdf guide for syntax. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite

[NMusers] RE: Using Microsoft MPI with NONMEM

Dear nmusers: The zip file msmpi_for_nonmem.zip in https://nonmem.iconplc.com/msmpi/ contains the contents of the entire msmpi folder for convenient download Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office:

[NMusers] Using Microsoft MPI with NONMEM

Dear nmusers: In response to recent requests to use Microsoft MPI with NONMEM, a procedure has been devised, and has been successfully applied to the 64 bit Windows 10 environment. Please go to https://nonmem.iconplc.com/msmpi and read msmpi_readme.pdf for instructions. Robert J. Bauer, Ph.D.

[NMusers] RE: This is a test #7001, please ignore

Testing ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If y

RE: [NMusers] How to format output table as purely comma-separated file

Well, this is not a strange behavior, this is a standard FORTRAN formatting process. Nonetheless, I can add a delimiter option that specifically removes spaces for future releases of NONMEM. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite

RE: [NMusers] Posting Guidelines in Group

Sumeet: Your postings should come through if you do the following: 1) Limit 4 characters (including appending dialog history from previous responses, so truncate if it gets too long) 2) No attachments 3) Only text and links Robert J. Bauer, Ph.D. Senior Director Pharmacometr

[NMusers] This is a test #7000, please ignore

Testing ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If y

[NMusers] RE: Sample distribution of etas

Tingjie: In NONMEM the most efficient and versatile way of obtaining samples from the posterior distribution for any parameters you desire is that shown by example 8 in the intro7.pdf manual in the section: Example 8: Sample History of Individual Values in MCMC Bayesian Analysis Robert J. Bau

RE: [NMusers] Strange PRED prediction in SAEM with M3 BQL handling

NONMEM 7.4.3 is the most up-to-date in usage of NPDE on BLQ records. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com

RE: [NMusers] How to Susbcribe ?

Send a message to nmusers-requ...@iconplc.com I have forwarded your request to our nmusers administrator. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 M

RE: [NMusers] Strange PRED prediction in SAEM with M3 BQL handling

Normally, the NONMEM reserved variable PRED will be automatically calculated for the user when the data is the typical normally distributed type. However, when data are modeled with a user specified likelihood (F_FLAG>0), the PRED value will be set to an uninformative value. To get around this

RE: [NMusers] Different OBJ after covariance with parallel and IMPMAP

c.com/> From: Robert Bauer [mailto:bobjba...@att.net] Sent: Friday, February 08, 2019 8:08 PM To: Bauer, Robert Subject: Fw: [NMusers] Different OBJ after covariance with parallel and IMPMAP - Forwarded Message - From: Mark Sale Cc: nmusers@globomaxnm.com Sent: ‎Monday‎, ‎February‎

[NMusers] ICON's NONMEM repository update, and F77 to f90 converter

Dear nmusers: The readme file to ICON's NONMEM repository, https://nonmem.iconplc.com/nonmem has been updated, called readme_nonmem_repository.txt at Also, a f77 to f90 converter has been added, to convert legacy *.f files into *.f90 files, for compatibility with NONMEM 7. This is located at: ht

[NMusers] Splines

Regarding Andre Jackson's query about using the Spline example in the NONMEM repository, the reason for the error message is that the appropriate OTHER routines, such as pack.f and single.f, that are referenced in the control stream file, need to be available. When using an example, it is good

RE: [NMusers] Potential bug in NM 7.3 and 7.4.2

Andreas: Thanks, this should allow me to determine how to resolve the issue. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com

RE: [NMusers] current sigma

Try the following examples, according to your need, in $PRED or $PK: SIGVAL11=SIGMA(1,1) OVAL22=OMEGA(2,2) IF(NEWIND.eq.0) WRITE(*,*) SIGVAL11,OVAL22 ... $TABLE SIGVAL11 OVAL22 Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersbu

RE: [NMusers] IMPMAP behavior question

Mark: You would also likely see in the .phi file that the OBJ values may be 0 for those subjects not collected. The solution is as Leonid said, increase TIMEOUT in the pnm file. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersbu

RE: [NMusers] How to calculate confidence interval (CI) and prediction interval (PI) of individual prediction (IPRED) in NONMEM

NONMEM 7.4 provides a straight-forward means of evaluating the standard error of IPRED and other table outputted parameters, by use of the option $TABLE … VARCALC=1. Please see nm743.pdf for more information on this, located at https://nonmem.iconplc.com/nonmem743 Robert J. Bauer, Ph.D. Senio

[NMusers] NONMEM 7..4.3

Dear NONMEM customers. A bug was inadvertently introduced in the NONMEM 7.4.2, which has been corrected in NONMEM 7.4.3: If MSFO option is used with IMP, SAEM, ITS, or BAYES, the problem fails with an access violation at the $COV step. If you typically use these new methods with the MSFO option

RE: [NMusers] Cleaning Up After NONMEM

Mark: You can create a batch file, such as nmfe74_cleanup.bat (or whatever name you wish), with contents such as call nmfe74.bat %* del *.set which will run the original nonmem script (and all arguments are passed with %*), and when done, go on to delete whichever files you wish. Robert J. B

[NMusers] FW: testing nmusers number 12001. Please ignore

Testing nmusers ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail addr

RE: [NMusers] [Suggest] NONMEM adds UTF-8 support for csv files

Mark: NONMEM does not use or interpret extended UTF-8 code, but perhaps you mean that NONMEM could filter out bytes>127 when reading in data files that are UTF-8 encoded, and process only bytes <=127. This can certainly be done, and I can add it to the list of improvements for the next release.

[NMusers] RE: Please help Winnie unsubscribe

s to find Cmax/Tmax Hi Nick, I have tried to unsubscribe multiple times to NMusers. Can you please help? Thanks, Winnie From: owner-nmus...@globomaxnm.com<mailto:owner-nmus...@globomaxnm.com> mailto:owner-nmus...@globomaxnm.com>> On Behalf Of Nick Holford Sent: Monday, May 14, 2018

[NMusers] RE: Using Root-finding techniques to find Cmax/Tmax

om: Nick Holford [mailto:n.holf...@auckland.ac.nz] Sent: Monday, May 14, 2018 9:54 AM To: Bauer, Robert; nmusers@globomaxnm.com Subject: RE: Using Root-finding techniques to find Cmax/Tmax Hi Bob, Thanks for preparing the examples. I found the “nonmem reserved general” file something of a challenge –

[NMusers] Using Root-finding techniques to find Cmax/Tmax

Dear nmusers: Because of the recent discussions (topic "Cmax/Tmax in the DES block") on the proper way of obtaining tmax and cmax with ODE solvers, I have been motivated to provide some examples utilizing root-finding techniques available in ADVAN14 (CVODES) and ADVAN15 (IDAS). Please read the

RE: [NMusers] Cmax/Tmax in the DES block

plc.com> www.iconplc.com<http://www.iconplc.com/> From: Leonid Gibiansky [mailto:lgibian...@quantpharm.com] Sent: Saturday, May 05, 2018 9:00 AM To: Bauer, Robert; nmusers@globomaxnm.com<mailto:nmusers@globomaxnm.com> Subject: Re: [NMusers] Cmax/Tmax in the DES block Thanks! Looking on ADVAN6 co

RE: [NMusers] Cmax/Tmax in the DES block

Leonid and Kyle: The code of ..\pr\ADVAN13.f90 (LSODA) is viewable and modifiable to the user, and it shows that ITASK=1 is always set. While for the short term you can change this setting and recompile ADVAN13, for the long term, I will look into adding an option at the control stream level,

RE: [NMusers] Cmax/Tmax in the DES block

Paolo and Kyle are correct on this point. ODE solving can be complicated, and each algorithm has its own method, calling the DES routine at will at various times T (which varies to a finer degree than TIME from the data set), sometimes carrying out an iterative process, until it has the satisfi

[NMusers] Principal Programmer Position

DOCS Global, an FSP Division of ICON Clinical, is currently recruiting for Principal and Senior Principal Pharmacometrics Programmers to be part of a large global biometrics and data operations FSP with a TOP Pharmaceutical company. Title: Principal / Senior Principal Pharmacometrics Programmer

[NMusers] testing nmusers number 12000. Please ignore

Testing nmusers ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail addre

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