> the original message.
-Original Message-
From: owner-nmus...@globomaxnm.com
[mailto:owner-nmus...@globomaxnm.com]on Behalf Of Nick Holford
Sent: Friday, August 21, 2009 16:44 PM
To: nmusers
Subject: Re: [NMusers] Linear VS LTBS
Leonid,
You are once again ignoring the actual evidence
Hi, my approach has been to use both LTBS and un-transformed data and then
see which one characterizes the data better. Then change initial estimates
and see how the model predicts.
My previous experience was when using untransformed with INTER the model was
not able to always converge specially wh
Mats
> I think you're missing an important point. As I wrote to Nick, you will
> never get concentrations reported regardless of their value. At some
> point,
> you will only get the information that concentration is below a limit
> (LOQ,LOD,LO?). This you should take into account in your design.
4003
-Original Message-
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Nick Holford
Sent: Monday, August 24, 2009 2:36 AM
To: nmusers
Subject: Re: [NMusers] Linear VS LTBS
Hi Mats,
I was wondering when you would join in this discussion :-)
Mats wrote:
&
5
fax: +46 18 471 4003
-Original Message-
From: Stephen Duffull [mailto:stephen.duff...@otago.ac.nz]
Sent: Monday, August 24, 2009 2:49 AM
To: Mats Karlsson; 'Nick Holford'; 'Leonid Gibiansky'
Cc: 'nmusers'
Subject: RE: [NMusers] Linear VS LTBS
Mats
Ju
Mats
Just a comment on your comments below:
"All models are wrong and I see no reason why the exponential error model would
be different although I think it is better than the proportional error for most
situations. "
"Why would you not be able to get sensible information from models that don
+46 18 471 4003
*From:* owner-nmus...@globomaxnm.com
[mailto:owner-nmus...@globomaxnm.com] *On Behalf Of *Nick Holford
*Sent:* Sunday, August 23, 2009 11:02 PM
*To:* Leonid Gibiansky
*Cc:* nmusers
*Subject:* Re: [NMusers] Linear VS LTBS
Leonid,
This is what I wanted to bring to the attention of
...@globomaxnm.com] On
Behalf Of Nick Holford
Sent: Sunday, August 23, 2009 11:02 PM
To: Leonid Gibiansky
Cc: nmusers
Subject: Re: [NMusers] Linear VS LTBS
Leonid,
This is what I wanted to bring to the attention of nmusers:
"Of course, I agree that overparameterisation could be a cau
gust 21, 2009 4:44 PM
To: nmusers
Subject: Re: [NMusers] Linear VS LTBS
Leonid,
You are once again ignoring the actual evidence that NONMEM VI will fail
to converge or not complete the covariance step more or less at random.
If you bootstrap simulated data in which the model is known and
f *Indranil
Bhattacharya
*Sent:* 20 August 2009 17:07
*To:* nmusers@globomaxnm.com <mailto:nmusers@globomaxnm.com>
*Subject:* [NMusers] Linear VS LTBS
Hi, while data fitting using NONMEM on a regular PK data set
and its log transformed vers
ment Solutions
ekaterina.gibian...@iconplc.com
-Original Message-
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
On Behalf Of Nick Holford
Sent: Friday, August 21, 2009 4:44 PM
To: nmusers
Subject: Re: [NMusers] Linear VS LTBS
Leonid,
You are once again ignoring
axnm.com
<mailto:owner-nmus...@globomaxnm.com>]*On Behalf Of *Indranil
Bhattacharya
*Sent:* 20 August 2009 17:07
*To:* nmusers@globomaxnm.com <mailto:nmusers@globomaxnm.com>
*Subject:* [NMusers] Linear VS LTBS
Hi, while data fitting using N
t:* 20 August 2009 17:07
*To:* nmusers@globomaxnm.com <mailto:nmusers@globomaxnm.com>
*Subject:* [NMusers] Linear VS LTBS
Hi, while data fitting using NONMEM on a regular PK data set
and its log transformed version I made the following
observations
onship is created
>>by this message by any person unless specifically indicated by
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>>*Monitoring: *AstraZeneca UK Limited may monitor email traffic data
>>and content for the purposes of the prevention and dete
bomaxnm.com>
[mailto:owner-nmus...@globomaxnm.com
<mailto:owner-nmus...@globomaxnm.com>]*On Behalf Of *Indranil
Bhattacharya
*Sent:* 20 August 2009 17:07
*To:* nmusers@globomaxnm.com <mailto:nmusers@globomaxnm.com>
*Subject:* [NMusers] Linear VS LTBS
as Eleveld
Van: owner-nmus...@globomaxnm.com namens Indranil Bhattacharya
Verzonden: vr 21-8-2009 13:52
Aan: Grevel, Joachim
CC: nmusers@globomaxnm.com
Onderwerp: Re: [NMusers] Linear VS LTBS
Hi Joachim, thanks for your suggestions/comments.
When using LTBS I had used a diffe
.
-Original Message-
From: Indranil Bhattacharya [mailto:ibhattacha...@gmail.com]
Sent: 21 August 2009 12:53
To: Grevel, Joachim
Cc: nmusers@globomaxnm.com
Subject: Re: [NMusers] Linear VS LTBS
Hi Joachim, thanks for your suggestions/comments.
When using LTBS I had used a different erro
Conduct and policies.
>
> -Original Message-
>
>
> *From:* owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
> *On Behalf Of *Indranil Bhattacharya
> *Sent:* 20 August 2009 17:07
> *To:* nmusers@globomaxnm.com
> *Subject:* [NMusers] Linear VS LTBS
&
ginal Message-
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]on
Behalf Of Indranil Bhattacharya
Sent: 20 August 2009 17:07
To: nmusers@globomaxnm.com
Subject: [NMusers] Linear VS LTBS
Hi, while data fitting using NONMEM on a regular PK data set and its log
Hi, while data fitting using NONMEM on a regular PK data set and its log
transformed version I made the following observations
- PK parameters (thetas) were generally similar between regular and when
using LTBS.
-ETA on CL was similar
-ETA on Vc was different between the two runs.
- Sigma was hi
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