I've just built perl6 successfully using rakudobrew on Alpine Linux
3.3.1 although I had to install build and header packages.
I saw some PAX alerts in the /var/log/message (probably moar uses an
executable stack) and had to disable this security checking with
paxctl (which I also had to install)
libuv does not like to build here, which is a dependency of MoarVM.
Though, that does not mean that we cannot do something about that.
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I don't know enough to dig much more into this, but I tried to build
both Rakudo Star 201