Re: Observations about facts in genomics

2013-03-22 Thread Phillip Lord
No, they don't. They have a responsibilty to do what they are being paid to do (or want to achieve for their own purposes) in a rapid and efficient manner. The point of standards is to make it easier to do this in the same way as others than to not. People write URLs correctly because otherwise t

Re: Observations about facts in genomics

2013-03-22 Thread Phillip Lord
Yeah, I have heard this argument before. Soon as you give me an assayable and testable definition for reality, I'm right with you. Phil Jerven Bolleman writes: > On Thu, Mar 21, 2013 at 2:55 PM, Phillip Lord > wrote: >> This is a broken definition of "good" to my mind. It suggests that we

Re: Observations about facts in genomics

2013-03-22 Thread Pat Hayes
On Mar 21, 2013, at 9:56 PM, Peter Ansell wrote: > On 22 March 2013 12:05, Alan Ruttenberg wrote: >> On Wed, Mar 20, 2013 at 3:15 PM, Jeremy J Carroll wrote: >>> >>> To me, that seems to lead us back to the earlier discussion (rathole?) >>> about owl:sameAs >>> I tend to a view that there are

Re: Observations about facts in genomics

2013-03-21 Thread Peter Ansell
On 22 March 2013 14:38, Alan Ruttenberg wrote: > On Thu, Mar 21, 2013 at 7:56 PM, Peter Ansell > wrote: >> On 22 March 2013 12:05, Alan Ruttenberg wrote: >> > On Wed, Mar 20, 2013 at 3:15 PM, Jeremy J Carroll >> > wrote: >> >> >> >> To me, that seems to lead us back to the earlier discussion (r

Re: Observations about facts in genomics

2013-03-21 Thread Alan Ruttenberg
On Thu, Mar 21, 2013 at 10:19 PM, Alan Ruttenberg wrote: > > > On Thu, Mar 21, 2013 at 10:15 PM, Pat Hayes wrote: > >> >> On Mar 21, 2013, at 11:38 PM, Alan Ruttenberg wrote: >> >> > >> > >> > On Thu, Mar 21, 2013 at 7:56 PM, Peter Ansell >> wrote: >> > On 22 March 2013 12:05, Alan Ruttenberg >

Re: Observations about facts in genomics

2013-03-21 Thread Alan Ruttenberg
On Thu, Mar 21, 2013 at 10:15 PM, Pat Hayes wrote: > > On Mar 21, 2013, at 11:38 PM, Alan Ruttenberg wrote: > > > > > > > On Thu, Mar 21, 2013 at 7:56 PM, Peter Ansell > wrote: > > On 22 March 2013 12:05, Alan Ruttenberg > wrote: > > > On Wed, Mar 20, 2013 at 3:15 PM, Jeremy J Carroll > wrote:

Re: Observations about facts in genomics

2013-03-21 Thread Peter Ansell
On 22 March 2013 15:15, Pat Hayes wrote: > On Mar 21, 2013, at 11:38 PM, Alan Ruttenberg wrote: >> On Thu, Mar 21, 2013 at 7:56 PM, Peter Ansell wrote: >> On 22 March 2013 12:05, Alan Ruttenberg wrote: >> > On Wed, Mar 20, 2013 at 3:15 PM, Jeremy J Carroll wrote: >> >> >> >> I am not sayin

Re: Observations about facts in genomics

2013-03-21 Thread Pat Hayes
On Mar 21, 2013, at 11:38 PM, Alan Ruttenberg wrote: > > > On Thu, Mar 21, 2013 at 7:56 PM, Peter Ansell wrote: > On 22 March 2013 12:05, Alan Ruttenberg wrote: > > On Wed, Mar 20, 2013 at 3:15 PM, Jeremy J Carroll wrote: > >> > > I am not saying that science presented as fact is infall

Re: Observations about facts in genomics

2013-03-21 Thread Alan Ruttenberg
On Thu, Mar 21, 2013 at 7:56 PM, Peter Ansell wrote: > On 22 March 2013 12:05, Alan Ruttenberg wrote: > > On Wed, Mar 20, 2013 at 3:15 PM, Jeremy J Carroll > wrote: > >> > >> To me, that seems to lead us back to the earlier discussion (rathole?) > >> about owl:sameAs > >> I tend to a view that t

Re: Observations about facts in genomics

2013-03-21 Thread Jeremy J Carroll
Alan, that is a superb message, very well-articulated I will ponder it. And as I said I don't really want to keep doing this theoretical dance and look forward to more substantive conversations. Jeremy On Mar 21, 2013, at 9:38 PM, Alan Ruttenberg wrote: > > > On Thu, Mar 21, 2013 at 7:

Re: Observations about facts in genomics

2013-03-21 Thread Peter Ansell
On 22 March 2013 12:05, Alan Ruttenberg wrote: > On Wed, Mar 20, 2013 at 3:15 PM, Jeremy J Carroll wrote: >> >> To me, that seems to lead us back to the earlier discussion (rathole?) >> about owl:sameAs >> I tend to a view that there are diminishing returns in terms of levels of >> indirection he

Re: Observations about facts in genomics

2013-03-21 Thread Alan Ruttenberg
On Wed, Mar 20, 2013 at 3:15 PM, Jeremy J Carroll wrote: > To me, that seems to lead us back to the earlier discussion (rathole?) > about owl:sameAs > Don't think so. It is a simple application of the pattern of having information about something. The statements don't have to be true. > > Yes,

Re: Observations about facts in genomics

2013-03-21 Thread Pat Hayes
Well, I don't quite know what to say. I feel a bit like a designer of cheap, workable, everyday town cars, and I have a customer who wants a Ferrari. I agree, Jeremy, you have a hard problem here. It sounds like you need statistical or probabilistic methods to keep track of these small likeliho

Re: Observations about facts in genomics

2013-03-21 Thread Jerven Bolleman
On Thu, Mar 21, 2013 at 2:55 PM, Phillip Lord wrote: > This is a broken definition of "good" to my mind. It suggests that we > should make all the distinctions that we can make, all the time. > Unfortunately, this means that everyone bears the cost of the complexity > all the time also. True but t

Re: Observations about facts in genomics

2013-03-21 Thread Phillip Lord
This is a broken definition of "good" to my mind. It suggests that we should make all the distinctions that we can make, all the time. Unfortunately, this means that everyone bears the cost of the complexity all the time also. A good data model should be an accurate reflection of biology. But

Re: Observations about facts in genomics

2013-03-20 Thread Andrea Splendiani
Hi, Good point. I personally find strange to deal with sequences in RDF. On one side, a sequence is a perfect identifier of itself (once if we factor out experimental errors). However, identity of sequences doesn't matter much (similarity of sequences is what counts). So we could have perfect id

Re: Observations about facts in genomics

2013-03-20 Thread David Booth
On 03/20/2013 06:15 PM, Jeremy J Carroll wrote: To me, that seems to lead us back to the earlier discussion (rathole?) about owl:sameAs Yes, we can model what we are doing at an arbitrary level of sophistication, but no, we may not want to. I tend to a view that there are diminishing returns in

Re: Observations about facts in genomics

2013-03-20 Thread Jeremy J Carroll
Is this issue wholly addressed by having a URI for the reference? Or is there some subtlety that I am missing here? i.e. I would expect a minor version of a reference genome to have a different URI from a different minor version of the same major version of the reference genome …. am I naive?

Re: Observations about facts in genomics

2013-03-20 Thread Graham Klyne
On 20/03/2013 22:09, Jerven Bolleman wrote: Hi All, This is fine in RDF, the important thing to separate is the concept of a Chromsome/Patient sequence and a set of observations and hypothesis about that Chromosome sequence. So instead of chromosome M you are really talking about assembly X of

Re: Observations about facts in genomics

2013-03-20 Thread Joachim Baran
Hello, On 20 March 2013 18:09, Jerven Bolleman wrote: > So instead of chromosome M you are really talking about assembly X of > a set of reads R mapped via some (variant calling) processes to > reference chromosome C that is also really an assembly of a different > set of reads. Just to add t

Re: Observations about facts in genomics

2013-03-20 Thread Jeremy J Carroll
To me, that seems to lead us back to the earlier discussion (rathole?) about owl:sameAs Yes, we can model what we are doing at an arbitrary level of sophistication, but no, we may not want to. I tend to a view that there are diminishing returns in terms of levels of indirection here! OTOH the

Re: Observations about facts in genomics

2013-03-20 Thread Jerven Bolleman
Hi All, This is fine in RDF, the important thing to separate is the concept of a Chromsome/Patient sequence and a set of observations and hypothesis about that Chromosome sequence. So instead of chromosome M you are really talking about assembly X of a set of reads R mapped via some (variant call

Re: Observations about facts in genomics

2013-03-20 Thread Graham Klyne
Hi Jeremy, On 20/03/2013 16:04, Jeremy J Carroll wrote: > One of the things I am learning about genetic sequencing is this process, which is meant to tell you about the patient's DNA, is in fact somewhat problematic, resulting in facts which are disputable. > It gets worse... the association

Observations about facts in genomics

2013-03-20 Thread Jeremy J Carroll
Pat Hayes wrote: "[RDF] is intended for recording data, and most data is pretty mundane stuff about which there is not a lot of factual disagreement." One of the things I am learning about genetic sequencing is this process, which is meant to tell you about the patient's DNA, is in fact somewha