Hi all, Here is some of the literature to consider.
>From PubMed Central (PMC): · A systematic review on clinical benefits of continuous administration of beta-lactam antibiotics. [Crit Care Med. 2009] Roberts JA, Webb S, Paterson D, Ho KM, Lipman J Crit Care Med. 2009 Jun; 37(6):2071-8. · Piperacillin-tazobactam for Pseudomonas aeruginosa infection: clinical implications of an extended-infusion dosing strategy. [Clin Infect Dis. 2007] Lodise TP Jr, Lomaestro B, Drusano GLClin Infect Dis. 2007 Feb 1; 44(3):357-63. · Outcomes of extended infusion piperacillin/tazobactam for documented Gram-negative infections. [Diagn Microbiol Infect Dis. 2009] Patel GW, Patel N, Lat A, Trombley K, Enbawe S, Manor K, Smith R, Lodise TP JrDiagn Microbiol Infect Dis. 2009 Jun; 64(2):236-40. · Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia. [Antimicrob Agents Chemother. 2009] Nicasio AM, Ariano RE, Zelenitsky SA, Kim A, Crandon JL, Kuti JL, Nicolau DPAntimicrob Agents Chemother. 2009 Apr; 53(4):1476-81. · Review A systematic review on clinical benefits of continuous administration of beta-lactam antibiotics. [Crit Care Med. 2009] Roberts JA, Webb S, Paterson D, Ho KM, Lipman JCrit Care Med. 2009 Jun; 37(6):2071-8. · The jury is still out on continuous infusion of beta-lactam antibiotics in intensive care patients. [Crit Care Med. 2009] van Zanten ARCrit Care Med. 2009 Jun; 37(6):2137-8. · Importance of nondrug costs of intravenous antibiotic therapy. [Crit Care. 2003] van Zanten AR, Engelfriet PM, van Dillen K, van Veen M, Nuijten MJ, Polderman KHCrit Care. 2003 Dec; 7(6):R184-90.You are here: · Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock Taccone et al. Critical Care 2010, 14:R126 Eileen P. Pummer MSN, RN, CPHQ, AACC, Quality Consultant Quality, Patient Safety & Effectiveness Dept. Stanford Hospital & Clinics Room: HC029 300 Pasteur Drive, (MC: 5306), Stanford, CA 94305 650-736-1728 (office), 650-213-6136 (cell), 650-725-0607 (fax) Do not follow where the path may lead. Go instead where there is no path and leave a trail. CONFIDENTIALITY NOTICE: The information contained in this e-mail message may be privileged, confidential and protected from disclosure. If you are not the intended recipient, any use, disclosure, dissemination, distribution or copying of any portion of this message or any attachment is strictly prohibited. If you think you have received this email message in error, please notify the sender at the above e-mail address, and delete this email along with any attachments. Thank you. From: [email protected] [mailto:[email protected]] On Behalf Of Mary Draper Sent: Wednesday, June 06, 2012 11:01 AM To: 'Shawver, Stephanie'; [email protected] Subject: Re: [Sepsis Groups] Extended Infusion Beta Lactam Antibiotics Do you have access to these studies? Our sepsis committee has not heard about this. Thanks. Please note: Will be on PTO June 12-20, returning the 21st Mary Draper RN BSN CCRN Quality Manager-Best Practice Support Quality Management Supervisor Office (925) 674-2045 Cell (925) 451-8792 Fax (925) 674-2373 [email protected]<mailto:[email protected]> [cid:[email protected]] From: [email protected]<mailto:[email protected]> [mailto:[email protected]]<mailto:[mailto:[email protected]]> On Behalf Of Shawver, Stephanie Sent: Friday, June 01, 2012 2:55 PM To: [email protected]<mailto:[email protected]> Subject: [Sepsis Groups] Extended Infusion Beta Lactam Antibiotics Colleagues, I am curious to hear feedback on the recent studies indicating that extended or continuous infusion of certain beta-lactam antibiotics have shown better outcomes for severe sepsis and septic shock patients. Our hospital's Sepsis Committee is considering changing the antibiotic regime on our protocol to have the applicable beta-lactam antibiotics infused over an extended period of time, if not continuous. Are there any other facilities out there going this route? Stephanie Shawver BSN, RN Infection Prevention Practitioner & SLMV Sepsis Coordinator St. Luke's Magic Valley 801 Pole Line Road West | Twin Falls, ID 83301 Office: (208) 814.3052 | Email: [email protected]<mailto:[email protected]> Infection Prevention Line: (208)-814-5120 " We are what we repeatedly do. Excellence then, is not an act but a habit." - Aristotle mg.slrmc.org made the following annotations --------------------------------------------------------------------- "This message is intended for the use of the person or entity to which it is addressed and may contain information that is confidential or privileged, the disclosure of which is governed by applicable law. If the reader of this message is not the intended recipient, you are hereby notified that any dissemination, distribution, or copying of this information is strictly prohibited. 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