I agree. The data in animal data and especially the concept that maintaining levels above the MIC for antibiotics with time-dependent killing are both compelling but the human studies have been mixed and generally unconvincing. How does infusion save money?
From: [email protected] [mailto:[email protected]] On Behalf Of Terry Clemmer Sent: Wednesday, June 06, 2012 12:00 To: Shawver, Stephanie; [email protected] Subject: Re: [Sepsis Groups] Extended Infusion Beta Lactam Antibiotics Stephanie When I read the literature carefully the evidence that it improves outcome is soft at best. That being said, in the Urban Central Region of Intermountain Healthcare we have gone to extended infusion of Vancomycin despite the inadequacy of the evidence that it saves lives because it financially made a difference in the cost. Terry P. Clemmer, MD Director of Critical Care Medicine LDS Hospital 8th Ave and 'C' Street Salt Lake City, Utah 84143 Phone 801-408-3661 E-mail: [email protected] <mailto:[email protected]> "Confidential Report for Improvement of Hospital, Facility and Patient Care--Not Part of Medical Record and Not to be Used in Litigation--Prepared Pursuant to Utah Code Ann. § 26-25-1 et seq., or Idaho Code Ann. § 39-1392 et seq." From: [email protected] [mailto:[email protected]] On Behalf Of Shawver, Stephanie Sent: Friday, June 01, 2012 3:55 PM To: [email protected] Subject: [Sepsis Groups] Extended Infusion Beta Lactam Antibiotics Colleagues, I am curious to hear feedback on the recent studies indicating that extended or continuous infusion of certain beta-lactam antibiotics have shown better outcomes for severe sepsis and septic shock patients. Our hospitals Sepsis Committee is considering changing the antibiotic regime on our protocol to have the applicable beta-lactam antibiotics infused over an extended period of time, if not continuous. Are there any other facilities out there going this route? Stephanie Shawver BSN, RN Infection Prevention Practitioner & SLMV Sepsis Coordinator St. Luke's Magic Valley 801 Pole Line Road West | Twin Falls, ID 83301 Office: (208) 814.3052 | Email: <mailto:[email protected]> [email protected] Infection Prevention Line: (208)-814-5120 We are what we repeatedly do. Excellence then, is not an act but a habit. - Aristotle mg.slrmc.org made the following annotations --------------------------------------------------------------------- "This message is intended for the use of the person or entity to which it is addressed and may contain information that is confidential or privileged, the disclosure of which is governed by applicable law. If the reader of this message is not the intended recipient, you are hereby notified that any dissemination, distribution, or copying of this information is strictly prohibited. If you have received this message by error, please notify us immediately and destroy the related message." ---------------------------------------------------------------------
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