You must consider the type of fluid you are giving. NS volume of distribution 
in only extracellular due the cell wall sodium pump. Most fat is intracellular 
and the saline will not be distributed into the fat cell. That is why we use 
predicted body weight. I agree with George Kramer the best would be Ideal body 
weight but that is not practical in the acute resuscitation scenario. When 
giving free water like D5W then the intracellular distribution needs to be 
taken into account.

Terry P. Clemmer, MD
Director: Critical Care Medicine
LDS Hospital
Professor of Medicine
University of Utah School of Medicine
Salt Lake City, Utan 84143

Work Phone: 801-408-3661
Work Fax: 801-408-1668

From: Sepsisgroups [mailto:[email protected]] On 
Behalf Of Barnes-Daly, Mary Ann
Sent: Thursday, May 29, 2014 4:19 PM
To: 'Kelsey K. Solano'; '[email protected]'
Subject: Re: [Sepsis Groups] Fluid Bolus in pts. with weight > 200 kg

Every recommendation that I have seen or heard, most recently from the faculty 
on the SSC, is to go with actual body weight.
Remembering that adipose tissue is highly vascular and contains a large amount 
of water and that the main 2 reasons for the fluid bolus are 1. Vasodilation 
reducing perfusion pressure and more importantly 2. Capillary leaking - and 
with all those miles (literally) of leaky capillaries obese patients have a 
very high propensity for intravascular volume depletion.


From: Sepsisgroups [mailto:[email protected]] On 
Behalf Of Kelsey K. Solano
Sent: Wednesday, May 28, 2014 7:05 AM
To: 
[email protected]<mailto:[email protected]>
Subject: [Sepsis Groups] Fluid Bolus in pts. with weight > 200 kg

I am wondering whether there are any recommendations regarding fluid 
resuscitation in patients weighing >200 Kg? Our physicians have expressed 
concern about the recommended fluid bolus for patients who are > 200 Kg and 
potential for CHF exacerbations. Are there any resources that address this 
concern or any modifications for this patient population? Also, is it always 
recommended to go with 30 ml/kg based on current weight or should we be 
calculating ideal weight when determining bolus volume? Currently we are using 
the patient's actual weight on admission for bolus calculations.  Any 
clarifications regarding the fluid bolus would be greatly appreciated.

Thanks,

Kelsey K. Solano
Sepsis Coordinator
Email: [email protected]<mailto:[email protected]>
Office: 574-335-2438

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