Hm. I see what you are saying, but I did not think that osmosis was due to solvency- but you are making sense. I am aware of the size factor in osmosis, but it seems that there are other chemical reactions or interactions going on that contribute to something being absorbed by the body, that can not be described satisfactorily by size alone. Take brain chemicals, for instance, there are many receptors etc that enter into the equasion in both the gut and the brain. I was under the impression that dmso is a different kind of solvent than either water or oil, as something in water will not penetrate the skin in the same way as when in dmso, ditto for oil. So dmso has a unique property that carries it into the skin.

I also thought that osmosis inside the body is somewhat mysterious, as there is a size factor, but I don't think that explains all of it. Reverse osmosis is solely a size filter, I thought.

Are you saying that you can dissolve something completely in dmso, and it will still be too large to be absorbed through the skin? is this due to pore size, or something else?

On Jan 16, 2008, at 1:59 PM, Marshall Dudley wrote:

I think you will find that the inability of a solvent to convey a solute which is greater than a certain molecular size is well documented. Look at osmosis an reverse osmosis. That is the name given to this action. Molecules greater than a certain size simply cannot cross a membrane barrier and get left behind. The question is not if it will happen with DMSO, but rather what sized molecules can penetrate the barrier, usually the skin for what we are talking about. It is easy to prove that large molecules in DMSO will not be absorbed into the body. Take a really big molecule, such as a 1/4 carat diamond, and put it into dmso. Then see if it will go through the skin. If you try it, you will find that it will just sit there.

Marshall

Clayton Family wrote:
I used to work for a horse vet, and he told me that it is a potent solvent, which is why it is so useful as a topical agent to carry medications for horses and other animals. He suggested I use gloves to handle it, as it carries lots of things inside the body with it when it goes, and he felt it was necessary to clean the area of the animals skin well before applying it. Since he had the practical experience dealing with it


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