Ode Coyote wrote:

>   I think the issue isn't that protein stabilizers are toxic but that the
> body assimilates them into the tissues along with the silver that's bound
> to those proteins, thereby, retaining and isolating the silver that would
> otherwise be free to roam about, do its thing and then be eliminated.
>  In other words, the silver bound to the proteins gets stuck, is less
> effective when stuck and being stuck, increases the chances of a high
> accumulation up to the possibility of a toxic concentration of silver or
> developing argryia...but the protein itself is as harmless as a hamburger.

By golly I think you have hit the nail on the head.  I never could figure out
how you could get argyria from the proteins before, but now it makes sense.

Here is what I think:

Argyria is caused by exactly the same process that film development uses.  That
is initially particles are formed or present which then grow when in the
presence of silver ions and a developer. If taking salts of silver particles
are formed upon exposure to light, thus argyria will only form in areas exposed
to light (which seems to be the case).  In the case of CS ions can also plate
out on the particles when the blood is alkaline and there is developer present
(I.E. caffeine).  But due to the ratio of particles to ions, the ions can only
grow so big before all the ions are used up, and they will not be big enough to
cause them to get trapped in tissues.  Even if a few did get trapped, they
would be trapped throughout the body mass, instead of just at the surface, so
it would not be seen.

In the case of silver protein, the proteins will get used where cells are being
replaced rapidly (this might make it good for treating cancer).  One of these
places is the skin which is continually shedding and being replaced.  Thus the
silver might get concentrated in the skin, then once it is there ionic silver
will plate out on the particles until they become big enough to absorb light
giving argyria again.

The only question is, when the proteins get split up to their base amino acids,
will the silver still be bound?

Marshall


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