Silver citrate solution was marketed as Itrol and is listed in
the U.S. Dispensatory, 1937, J.B. Lippincott Co. Phila.
and would be included in Hill & Pillsbury reference to
argyria being associated with every silver compound in
clinical use in 1939, except silver oxide.
Incidentally, Hill and Pillsbury note that the use of
silver cutlery has never been associated with argyria in
modern times.
Hill and Pillsbury wrote before the discovery of LVDC
EIS. On page 45 of their book, footnote 1, they note
that saturated solution of silver oxide (1520 milligrams
per kilogram of water) in doses of 4 milliliters taken
3 times daily over a period of 3 weeks produced in
various animals neither toxic effect nor argyrial
pigmentation.These results support their exclusion of
silver oxide from the compounds that lead to argyria.
Perhaps an epidemiological inference could then be made
that the dissolved compound in EIS is silver oxide.
If I am not mistaken, others have reached this very same
conclusion from entirely different evidence and/or
reasoning.
Matthew
