I can only speak for the database search step, but I've never seen any of the major search engines use more than a gig of RAM on a high-end data set (~30k spectra) with a large database (UniRef-100 FTW!). As long as there is free physical RAM at all times during a search, adding more RAM is not going to speed things up noticeably. If you start using a box for multiple purposes (i.e. hosting multiple servers, VMs, etc.) that's when you need to bump up the RAM and usually go 64-bit on the OS (although not necessarily on the applications).
-Matt AndrewK wrote: > Thanks Matt. It was my assumption that 32bit apps generally have no > problem running on Vista. I guess the issue is they cannot take > advantage of the additional processing bandwidth (?). > > Memory limitations on 32 bit platforms appears to be 4Gb per > processor. Is this a wrong assumption? The duo core chips can take no > more than 8Gb DDR DIMMS, whereas Xeons can go way higher, but If it is > a 32bit application, does the Xeon access all of the memory available > to the quad processors while running that 32bit app? In other words, > would you have to have more than 16 Gb of memory on a Xeon to get > similar performance to a duo core with 8Mb? Those larger memory > architectures get pricey fast (though I guess the xeons have bigger L2 > cache as well). > > Memory seems to be an important consideration in getting faster search > times, but can 32bit applications actually utilize more than 4Gb of > that 8Gb of memory? If not, then it seems that You have to go Xeon > with more than 16Mb of memory to get faster searches (and similar Xeon > clock speeds are more pricey than the same speeds on the duo core > chips). > > I just don't want to make a stupid mistake. > > On Sep 3, 11:37 am, Matthew Chambers <matthew.chamb...@vanderbilt.edu> > wrote: > >> Speaking for ProteoWizard, I run Vista 64-bit at home and the 32-bit >> binaries work fine. I haven't dared to compile the 64-bit binaries >> because they wouldn't work with the vendor DLLs anyway. I suspect TPP's >> 32-bit binaries will work fine as well. >> >> -Matt >> >> AndrewK wrote: >> >>> I don't see hardware or OS limitations for the Windows version(s) of >>> SPCtools. I'll be using Extract_MSN (as well as ReAdW), and am >>> ordering a computer for this platform. >>> >>> Is Vista 64bit OK? >>> >>> Andrew >>> UMKC-Proteomics >>> Kansas City >>> > > > > > --~--~---------~--~----~------------~-------~--~----~ You received this message because you are subscribed to the Google Groups "spctools-discuss" group. To post to this group, send email to spctools-discuss@googlegroups.com To unsubscribe from this group, send email to spctools-discuss+unsubscr...@googlegroups.com For more options, visit this group at http://groups.google.com/group/spctools-discuss?hl=en -~----------~----~----~----~------~----~------~--~---
