Daniel,

The issue you're seeing might be due to TPP windows programs compiled as
32-bit binaries.  The first thing I'd try is grabbing a 64-bit binary of
one of the tools to see if that fixes things.  You can grab a 64-bit Comet
binary from its SourceForge download site if you want to test this.  I wish
I could tell you definitively that the 64-bit Comet binary will work for
you but I just don't have access to files >2GB to test with.


On Fri, Oct 9, 2015 at 11:09 AM, Daniel Hyduke <danielhyd...@gmail.com>
wrote:

> I've recently noticed some failures when using comet and xtandem! from TPP
> to search some centroided DDA files generated by qtofpeakpicker.  These
> failures were all associated with files > 2GB.  I was able to reduce the
> file size by increasing the threshold which then lead to readmzXML, tandem,
> and comet actually reading the files and searching them.  I'm guessing that
> there's a place in the TPP mzXML code that uses an int (which is 32-bit)
> that's causing this problem.
>
> I've used TPP 4.8.0 on Windows 7 (installed via the exe provided on
> sourceforge) and built the tpp from the svn on GNU/Linux (centos 7) and
> encountered the same problem.
>
> I was wondering if anybody had any thoughts on where I should start
> sifting through the code?
>
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