http://seattletimes.nwsource.com/html/nationworld/2001802658_superbug28.html
The Seattle Times
Friday, November 28, 2003

Coming attraction: a bug that'll devour toxic waste

By Robert S. Boyd
Knight Ridder Newspapers


WASHINGTON - Scientists are working to perfect a "superbug" that they 
think can help clean up toxic wastes at thousands of radioactive 
nuclear sites around the world.

The mighty microbe - nicknamed "Conan the Bacterium" - combines the 
genes of two bacteria to perform a job neither could do on its own.

The composite creature "can live quite happily in an environment with 
1 million times the radiation a human cell could tolerate," Energy 
Secretary Spencer Abraham said at a news conference this month.

Conan works because the radiation-resistant bacterium (Deinococcus 
radiodurans) shelters the twosome from lethal rays, while its partner 
(Pseudomonas putida) uses its native ability to render poisons in 
soil or water harmless.

"Our scientists have shown that it is possible to combine Conan's 
radiation-resistance properties with the capabilities of other 
microbes," Abraham said. "We are ready to turn it to our own uses."

The Energy Department estimates there are about 3,000 sites 
contaminated with 40 million cubic yards of toxic wastes - many of 
them radioactive - left over from the Cold War.

"Some of these waste sites are really hot - they're cookin'!" said 
Michael Daly, a biologist at the Uniformed Services University of the 
Health Sciences in Bethesda, Md.

Daly and genome-wizard Craig Venter, founder of The Institute for 
Genomic Research in Rockville, Md., determined the complete sequence 
of the Deinococcus genome in 1999. Daly continues to work on 
practical applications of the modified microbe in his laboratory.

One application under development might help cancer patients resist 
the unpleasant side effects of radiation therapy.

"It's very exciting," Daly said. "There are more things to come that 
I can't talk about yet."

Conan can break down the chemical structure of toluene - an 
ingredient in explosives such as TNT that contaminate many Energy 
Department waste sites - leaving only carbon dioxide and water.

"You can't get less toxic than that," Daly said.

Copyright © 2003 The Seattle Times Company


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