http://www.precaution.org/lib/06/prn_stop_the_killing.pt1.060921.htm

Rachel's Democracy & Health News #876, October 12, 2006

Some Chemicals Are More Harmful Than Anyone Ever Suspected

[Rachel's introduction: Evidence is piling up to show that many 
chemicals can cause serious illnesses, which then can be passed on to 
our children and grandchildren.]

By Peter Montague

New evidence is flooding in to suggest that many industrial chemicals 
are more dangerous than previously understood. During the 1990s, it 
came as a surprise that many industrial chemicals can interfere with 
the hormone systems of many species, including humans. Hormones are 
chemicals that circulate in the blood stream at very low levels 
(parts per billion, and in some cases parts per trillion), acting 
like switches, turning on and off bodily processes. From the moment 
of conception throughout the remainder of life, our growth, 
development and even many kinds of behavior are controlled by 
hormones.

Now new evidence is piling up to show that some of these 
hormone-related changes can be passed from one generation to the next 
by a mechanism that remains poorly understood, called epigenetics.

Until very recently scientists had thought that inherited traits 
always involved genetic mutations -- physical changes in the sequence 
of nucleotides that make up the DNA molecule itself. Now they know 
that there is a "second genetic code" that somehow influences the way 
genes operate, and that by some poorly-understood mechanism can be 
passed along to successive generations.

Medical scientists hope to take advantage of the new science of 
epigenetics to manipulate the behavior of genes for beneficial 
purposes. But the dark side of this new understanding is that stress, 
smoking, and pollution can cause epigenetic changes -- including many 
serious diseases like cancer and kidney disease -- that apparently 
can be passed along to one's children and even grandchildren. For 
example, Dutch women who went hungry during World War II gave birth 
to small babies. These babies, in turn, gave birth to small babies 
even though they themselves had plenty to eat. "It changes the whole 
way we think about inheritance," says Dr. Moshe Szyf at McGill 
University in Toronto.

Just last month professor Michael Skinner at Washington State 
University in Spokane announced results of laboratory experiments 
<http://www.precaution.org/lib/06/prn_cancer_toxin_connection.060915.h 
tm> showing that environmental pollution could permanently reprogram 
the genetic traits of a family line of rodents, creating a legacy of 
sickness. This research "highlights the long-term dangers from 
environmental pollution," professor Skinner said. Dr. Skinner showed 
that a single exposure to a toxic chemical in the womb could produce 
a sick litter of offspring, which in turn could produce its own sick 
offspring. "It's a new way to think about disease," Dr. Skinner said.

"A human analogy would be if your grandmother was exposed to an 
environmental toxicant during mid-gestation, you may develop a 
disease state even though you never had direct exposure, and you may 
pass it on to your great-grandchildren," Skinner said.

"It introduces the concept of responsibility into genetics," says Dr. 
Szyf. As a recent story in the Toronto Globe & Mail 
<http://www.precaution.org/lib/06/prn_code_2.060311.htm> summarized, 
"Epigenetics may revolutionize medicine, said Dr. Szyf, and it also 
could change the way we think about daily decisions like whether or 
not to order fries with a meal, or to go for a walk or to stay in 
front of the television. You aren't eating and exercising for 
yourself, but for your lineage."

On average, 1800 new chemicals are registered with the federal 
government each year and about 750 of these find their way into 
products, all with hardly any testing for health or environmental 
effects.

Brominated flame retardants, phthalates, bisphenol-A, PFOA (related 
to the manufacture of Teflon) are the toxins that have gained our 
attention at the moment. By working overtime for 10 or 15 years in 
the traditional environmentalist way, we may be able to ban a 
half-dozen of them. But during that 10 or 15 years, the chemical 
industry (and the federal EPA) will have introduced somewhere between 
7,000 and 10,000 new chemicals into commerce, almost entirely 
untested. This destructive merry-go-round is accelerating.

Faced with evidence of harm, governments tend to respond initially by 
conducting "risk assessments" to show there is no problem. The main 
function of risk assessment is to make chemical problems disappear, 
almost like magic. As EPA's first administrator, William Ruckelshaus, 
reminded us, "We should remember that risk assessment data can be 
like the captured spy: If you torture it long enough, it will tell 
you anything you want to know."

So the bad news about chemical contamination is steadily mounting, 
while the number of new chemicals is steadily increasing. As we have 
been reporting regularly in Rachel's Precaution Reporter, 
<http://www.precaution.org/lib/06/ht061011.htm> the European Union 
has responded to this situation by trying to enact a new law called 
REACH, which requires that chemicals be tested before they can be 
sold. As they say in Europe, "No data, no market." The U.S. and 
European chemical industries -- and the White House -- have been 
working overtime to subvert the European effort to enact REACH. But 
now it looks as though REACH -- in one form or other -- will become 
law soon. It will be binding on any corporations that want to sell 
chemicals in Europe, including firms based in the U.S.


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