Your Genetic Code Is Not Carved in Stone

By Al Sears, MD

New research is revealing how your environment actually changes your genetics - 
and it's putting you in the driver's seat. 
In November, the Children's Hospital Oakland Research Institute released the 
results of their groundbreaking study. They found that a mother's diet during 
pregnancy not only affects her child, but also her child's offspring. 
This means that the lifestyle choices a woman makes can affect several 
generations of children - a revolutionary idea that flies in the face of 
conventional wisdom. 

For more than 150 years - since the time of Darwin - scientists have believed 
that any changes to an organism cannot be passed on to the next generation. 
According to strict Darwinism, if you were to change your diet, lose weight, 
and become super-fit, your children would not benefit from your efforts. But we 
now know there is something more at play: the "epigenome." The epigenome plays 
a powerful role in your health... and could make the difference between whether 
or not you "inherit" heart disease or diabetes or something else.

Scientists in an emerging field of research - epigenetics - have discovered 
that your genes are only 15 percent of the total genetic material you get from 
your parents. For example, your genes give you many individualizing traits like 
blue eyes or brown hair. The remaining 85 percent - the epigenome - is a 
scaffolding of proteins that surround your DNA's double-helix pattern. 
As it turns out, this "scaffolding" functions as an interface that interacts 
with your environment. Based on the lifestyle choices you make, the epigenome 
has the power to turn genes on or off, changing the way your body translates 
your genetic coding into the proteins that make up YOU. 

The Children's Hospital Oakland study, lead by Dr. David Martin, split 
genetically identical pregnant mice into two groups. The mice had been bred in 
a way that gave the scientists the ability to monitor a gene that determined 
both the color of their coats and their tendency to develop chronic disease. 
So, by tracking coat color, they were able to follow the effects of vitamin 
supplementation across two generations of offspring. 

The first group of mice received a standard diet. The second group received the 
same diet, with the added benefit of supplemental vitamin B12, folate, choline, 
and zinc. When the babies were born, the females from both groups were mated 
and fed identical diets with no supplements. When the offspring gave birth, Dr. 
Martin's team discovered that the original mice that had the diet with extra 
vitamins passed the benefits on to both their children and grandchildren.

Findings like these have powerful implications in both directions. It means 
that, by making healthy choices, your efforts can have a positive effect not 
only on your children but on your grandchildren as well. On the other hand, a 
diet of fast food and sodas will not only wreck your own health, it could 
predispose future generations to chronic diseases like obesity, diabetes, and 
heart disease. 
That helps to explain why so many schoolchildren suffer from high blood 
pressure and low HDL (good cholesterol). The poor dietary choices their parents 
made are coming home to roost. 

This discovery gives us new insight into a long-standing debate between Charles 
Darwin and a guy you may never have heard of - French naturalist Jean-Baptiste 
Lamarck. 
Darwin's theory, which has been shaping the direction of modern science, can be 
summed up in a few words: Genes cannot be affected by the outside world. In 
other words, your lifestyle choices have no effect on your genetic code or how 
those genes are expressed.

But Lamarck believed that if an organism changes during its life in order to 
adapt to its environment, those changes would be passed on to its offspring - 
and Dr. Martin's study is one of several that are proving he was correct.
So, guess what? It looks like you're no longer a "victim" of your genetic 
programming. If, for example, if you decide to exercise vigorously to develop 
new muscle, it now appears that it's possible for you to pass on a 
predisposition to build muscle with exercise to your children... and perhaps 
even further down your line of descendants. 

Conscious decisions to improve your health will interact with your epigenome. 
In turn, the proteins in your epigenome can turn off genes that would have 
otherwise expressed themselves as disease in your descendents. 
Instead of the old model, think of your genetic code as a library. You have 
thousands of choices, but you never check out all of the books. The epigenome 
interacts with your environment and your choices to determine which books to 
"read." 

Your Genetic Code Is Not Carved in Stone
Vitamins like E, C, and A send messages to your genes that normalize cell 
division. This alone can aid in preventing many forms of cancer. 
For vitamins E and C, I recommend taking more than the U.S. government 
suggests. Start with 100 IUs of vitamin E and 2,000 mg of vitamin C daily.

Here are four other nutrients that powerfully support detoxification and proper 
genetic expression:
Vitamin B12: 500 to 1,000 mcg daily 
Folic acid: 500 to 1,000 mcg daily 
Vitamin B6: 10 to 20 mg daily 
Betaine [Betaine HCL aka TMG]: 200 to 1,000 mg daily 

Don't sit back and allow "bad genes" to ruin your health. Take action and make 
yourself and future generations healthier. 
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