Here's a simpler example:

from numpy import *
from sympy import *

x = array([(1.1, 2.2), (3.3, 4.4), (5.5, 6.6)], dtype=[('s0', '<f8'), 
('s1', '<f8')])

eq = 2.0 * Symbol('s0') - Symbol('s1')

2.0*x['s0']-x['s1'] # Gives correct result at command prompt

eq.evalf(x) # Fails

The constraints are that the symbols in the equation are unknown, and there 
is a random number of them that can be huge, like thousands of variables as 
symbols. What is provided is the time course data x and the equation eq 
which contains matching variables. I.e., The code has no way of knowing 
beforehand what the variables are going to be, nor how many so a predefined 
lambda will not solve the problem.

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