Hi:

Isotopes of an element differ in the number of neutrons.  The chemical reactions of an element are governed by the electrons, which are the same for all isotopes, so chemical means can not be used to separate the isotopes.
There are a number of ways of making the separation, for Uranium see:
https://en.wikipedia.org/wiki/Clinton_Engineer_Works#Facilities

It's not clear to me how the isotopes of water are accounted for in it's physical properties.  Have these been refined and defined for each isotope?  This may be important since the properties of water show up a lot as the basis for other definitions.
https://en.wikipedia.org/wiki/Isotopes_of_hydrogen
https://en.wikipedia.org/wiki/Isotopes_of_oxygen

PS One of the names of the company I worked for was FEI Microwave. There was a rumor that the funder of that company had a bunch of very special quartz in the vault and that crystals cut from that material had better phase noise than off the shelf crystals hence he had an advantage over other vendors.
http://prc68.com/I/Aertech.shtml#Names

--
Have Fun,

Brooke Clarke
http://www.PRC68.com
http://www.end2partygovernment.com/2012Issues.html

-------- Original Message --------
Single isotope diamond is 50% better  thermal conductivity of normal diamond.   
It has been  used in laser optics and thermal transfer applications 
(semiconductor heatsinks).   I think the highest reported thermal transfer rate 
used isotopically pure diamond etched with micro-fluidic channels fed with 
coolant.   GE makes the diamond material... it was developed as part of 
Reagan's Star Wars project.

Isotopically pure silicon has 60% better thermal conductivity than natural 
silicon.

Isotopically pure platinum has been used in RTD temperature sensors.
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