If you have no 3D hardware acceleration Blender will still work. Everything will be software rendered by the CPU. I've used Blender extensively on a system with Trisquel 5.5 and a Radeon GPU. Although a bit slow, it's usable.

I still haven't used Trisquel 6.0 on a Radeon system, so I don't know if there are any problems with Blender there.

Armworm, if you use a Radeon GPU you should not have 3D hardware acceleration.

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