Interesting question - what will be the end platform.

If you really want a python solution:
Tablets. phones, desktops - Kivy (very promising)
Tablets. phones, desktops - PyQt
Desktops - wxPython, tk, Dabo (python 2.7 at the moment)

All the other GUI frameworks either have a very small following or are dying (my opinion of course).

If you are not concerned with what language is used:
Consider all the web frameworks.
Several of the web frameworks work on the desktops, and are browser friendly. Atom/electron (not sure about the name)
but in general web frameworks (no matter which one) is all about browsers.

Johnf

On 06/13/2015 10:15 AM, Laura Creighton wrote:
The final thing to consider is, do you really want to do gui programming
at all, or would you be happier developing something that runs in a browser?
If that has appeal, well, you guessed it, we have lots of browser
frameworks, as well.

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