I can add that I've also tried with the kernel 4.15.0-36.39 from Ubuntu 18.04 and the problem also reproduced. Right now I also suspect systemd/udev or userspace ALSA components because, although I can play sounds on the "default" and "sysdefault" devices, I cannot play on "D2X" or "surround51" devices:
$ aplay -D hw:D2X /usr/share/sounds/alsa/Front_Center.wav aplay: main:828: audio open error: Device or resource busy I know no application is using the sound device, "fuser -v /dev/snd/*" output is empty. -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1799541 Title: ASUS Xonar D2X not detected in PulseAudio To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/linux/+bug/1799541/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs