Thank you to both for your answers. Yes, I meant TxRep.
My text file is in this format: mail@mydomain,remote_email@remotedomain My goal is to lower the score of messages coming from remote_email@remotedomain and addressed to mail@mydomain. Of course, each user can have a different list of addresses and as I said, there are about 610.000 lines in the file. There are 360.000 unique remote_emails in the file...