Thank you to both for your answers.

Yes, I meant TxRep.

My text file is in this format:
mail@mydomain,remote_email@remotedomain

My goal is to lower the score of messages coming from
remote_email@remotedomain and addressed to mail@mydomain. Of course, each
user can have a different list of addresses and as I said, there are about
610.000 lines in the file.

There are 360.000 unique remote_emails in the file...

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