If your serial interface uses the older Prolific 2303 chipset it may be
running into a common driver problem with this component. Evidently at
some point Prolific modified their driver to test for and disable the
counterfeit Chinese versions of the chip. You can do a search for the
earlier version of the driver and replace the Win10 installed version of
the driver and things will work again.
You can check if it's a driver problem:
Open Device Manager
Click on Ports
Right click on the serial port you're using for rig control.
Select "Properties"
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