See this thread for information on load testing for vmware:
http://communities.vmware.com/thread/73745?tstart=0&start=0

Within the thread there are instructions for using iometer to load test your 
storage. You should test out your solution before going live, and compare what 
you get with what you need. Just because striping 3 mirrors *will* give you 
more performance than raidz2 doesn't always mean that is the best solution. 
Choose the best solution for your use case.

You should have at least two NICs per connection to storage and LAN (4 total in 
this simple example), for redundancy if nothing else. Performance wise, vsphere 
can now have multiple SW iSCSI connections to a single LUN. 

My testing showed compression increased iSCSI performance by 1.7x, so I like 
compression. But again, these are my tests in my situation. Your results may 
differ from mine.

Regarding ZIL usage, from what I have read you will only see benefits if you 
are using NFS backed storage, but that it can be significant. Remove the ZIL 
for testing to see the max benefit you could get. Don't do this in production!

-Scott
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