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Some observations...

a) Supplementary materials are rarely (ever?) formatted by the publisher. For the journals I've been submitting to, we submit a pdf file that is put directly on the site. Journal styles, units, abbreviations, formatting preferences, etc. are not examined. I've seen spelling mistakes, and obvious typos here that would never made it into the primary citation. It would seem to me that people are just throwing together such materials as a catchall.

b) Referencing the materials from the main text is useful - but there should be a sufficient description explaining what is there. If the main text just has (see figure S1) - what will I find there? Is it relevent to my understanding? I need to make the effort to find the materials to see if they are relevant. Maybe a table of contents for the s. materials could be added to the main article...

c) As commented before - access to the supplementary materials is free. However, unless you are reading the journal online - there is a tremendous effort required to access the materials. You have to find the journal website, and then locate the particular article. On some journals, you can type in volume, page - others require that you use the graphical tree heirarchy to find the article.

d) When are supplementary materials appropriate? There are variety of situations - but the ones I like the best are ones that contain information determined from sequence databases. Sequencing projects are ongoing all the time - a blast search run today may give differing results a year later as new genomes come online. The supplementary materials might contain the accession numbers of sequences used in the text - particularly if sequences are a composite of ESTs, etc. I consider this a snapshot of a lab notebook. It shows how the authors may have assembled that sequence alignment shown in the primary text, or how they selected conserved
residues indicated on a figure of a 3D structure.

e) When are supplementary materials inappropriate? When they contain information critical to reproducing the results in the publications. I know more and more of the materials and methods are being shoved into the supplementary materials - but I fear that such information may turn out to be critical to the understanding of experiments and interpreting results. Can you imagine if the text of a paper indicates "kinetics were preformed using standard procedures" and a reference given - and only in the supplementary materials do you find out that of the dozen different protocols they followed - they chose one known by experts in the field to be flawed due to choice of buffer?

What is there to be done? The Science and Nature out there are always looking for ways to reduce space - putting materials & methods into footnotes, etc. In this case the supplementary materials could allow an author the space to flush out all the details.

What is important however is that the supplementary materials gets reviewed, indexed and formatted by the journal. The suplpementary material is part of the publication and should be treated with the same critical eye as the main publication.

Just my 2 pence....

Ezra

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