Ethan,

I still don't understand.  Real space refinement will minimize a fit
of model to density in whatever map you give it.  It's up to you
which coefficients are used to calculate the map you are refining
against.

This is true.
However, I guess, the way it is implemented in Coot is a bit different (Paul, please correct me if I'm wrong).
Compare slides #4 and #5:
http://cci.lbl.gov/~afonine/rsr.pdf

Pavel.

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