On Jan 17, 2011, at 11:46 AM, James Holton wrote: > > I am willing to bet that the earliest "no method" entries (particularly the > ones that lack a REMark 200 record) were probably MIR, since that was the > "obvious" method to solve a structure for some time. Modern "NULL" entries > seem to be mostly what I call "molecular replacement", which includes just > refining from a native, etc. not necessarily running an MR search program.
I was taught to refer to this method of solution as "isomorphous replacement," as long as the space group and/or unit cell had not changed so much that rigid body refinement could not lower the free R-factor enough for conventional refinement to proceed. Diana * * * * * * * * * * * * * * * * * * * * * * * * * * * * Diana R. Tomchick Associate Professor University of Texas Southwestern Medical Center Department of Biochemistry 5323 Harry Hines Blvd. Rm. ND10.214B Dallas, TX 75390-8816, U.S.A. Email: diana.tomch...@utsouthwestern.edu 214-645-6383 (phone) 214-645-6353 (fax) ________________________________ UT Southwestern Medical Center The future of medicine, today.
