Would it be true that the anomalous differences could not be measured in these types of datasets, because one would not know which Friedel/Bivoet reflection one is measuring in a given frame? Perhaps, given anomalous signal, there would be a way to tease out which orientation one was looking at from the correlations of the signs/magnitudes of anomalous-scattering-induced deviations from the mean intensities (derived from the whole dataset) for all of the relections observed in each frame? I guess this might also detwin the data?
JPK On Thu, Feb 10, 2011 at 7:17 AM, Anastassis Perrakis <a.perra...@nki.nl> wrote: >> >> Anyway, I thought that was a cool idea, but like so many other cool >> things, it had to be cut from the Nature paper. Admittedly, the problem has >> not actually been solved yet. This is why we used REFMAC in TWIN mode. > > Is that a hint on the: > > a. wisdom of the editor > b. wisdom of 'the third referee' > c. wisdom of the dogma 'five years of eight eight lifes in 2000 words' > d. All of the above > > ;-) > > A. > -- ******************************************* Jacob Pearson Keller Northwestern University Medical Scientist Training Program cel: 773.608.9185 email: j-kell...@northwestern.edu *******************************************
