On Fri, Feb 10, 2012 at 12:29 PM, James Stroud <xtald...@gmail.com> wrote: > How could they not be snapshots of conformations adopted in solution?
Packing billions of copies of an irregularly-shaped protein into a compact lattice and freezing it to 100K isn't necessarily representative of "solution", especially when your solution contains non-physiological amounts of salt and various organics (and possibly non-physiological pH too). -Nat
