Hi Jacob, Lorena Beese has a few systems where snapshots of reaction mechanisms have been looked at structurally.
Here are two such papers: Long, SB, Casey, P., Beese, LS (2002) The reaction path of protein farnesyltransferase at atomic resolution. Nature Oct 10; 419(6907):645-50. http://www.ncbi.nlm.nih.gov/pubmed?term=The%20reaction%20path%20of%20protein%20farnesyltransferase%20at%20atomic%20resolution J. R. Kiefer, C. Mao, J. C. Braman and L. S. Beese (1998) “Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal” Nature 6664:304-7. http://www.ncbi.nlm.nih.gov/pubmed?term=Visualizing%20DNA%20replication%20in%20a%20catalytically%20active%20Bacillus%20DNA%20polymerase%20crystal Cheers, -bob On Fri, Feb 10, 2012 at 3:25 PM, Jacob Keller <j-kell...@fsm.northwestern.edu> wrote: > Dear Crystallographers, > > I am looking for references which discuss the validity of the > assertion that multiple crystal structures of the same or similar > proteins can be considered freeze-frame snapshots of actual > conformations assumed in solution. In a way, the assertion seems > almost definitely true to me, but on the other hand, I could imagine > some objections as well. Seems there should be some classic literature > here... > > All the best, > > Jacob > > > > -- > ******************************************* > Jacob Pearson Keller > Northwestern University > Medical Scientist Training Program > email: j-kell...@northwestern.edu > *******************************************
