Hi Jacob,
Ion-channel and receptor folks have been working on these types of
questions... see: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629458/
if you are looking for a model system, perhaps engineer a version of
calmodulin that is specific for Na+ rather than Ca++? Perhaps someone
has already done that.
-Conn
Conn Mallett, PhD
Carlsbad, CA
conn.mallett<at>gmail.com
skype: conn.mallett
On 9Jan2018 06:42, Keller, Jacob wrote:
Dear Crystallographers,
Is anyone aware of a soluble protein which changes large-scale
conformation +/- Na+, and is specific for Na+ per se, or at least
ignores K+ and Ca++? E.g., Rb+ or Li+ might be okay. Structural info
would be a plus, but not a sine qua non.
Similarly, what about with K+ or Cl- specificities, but oblivious to
similar common ions?
All the best,
Jacob Keller
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Jacob Pearson Keller
Research Scientist / Looger Lab
HHMI Janelia Research Campus
19700 Helix Dr, Ashburn, VA 20147
(571)209-4000 x3159
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