Hi Everyone, I want to crystallize a small organic molecule. I have very limited experience in small molecule crystallography. I found that the Crystal Screen HT from the Hampton research is good for both small molecule and macromolecule crystallization. Plan to set up a sitting drop screen just like setting up protein crystallization. I don’t know if this is the proper way to do it. Is the MRC sitting drop 2-well plate (HR3-083) used for protein crystallization good for small molecule crystallization? Are there any special plates used for small molecule crystallization? Is room temperature ok or not?
For data collection, can I use the beamline for protein crystals to collect data on small molecule crystals? Larger oscillation angle, shorter exposure, reduced beam intensity? For structure determination, is SHELXL the preferred software for solving small molecule structures? If anyone has experience in small molecule crystallography, please help. Thanks! Best Regards, -- *Jiyuan Ke, Ph.D.* Research Investigator H3 Biomedicine Inc. 300 Technology Square, Floor 5 Cambridge, MA 02139 Phone: 617-252-3923 Email: jiyuan...@h3biomedicine.com Website: www.h3biomedicine.com -- [This e-mail message may contain privileged, confidential and/or proprietary information of H3 Biomedicine. If you believe that it has been sent to you in error, please contact the sender immediately and delete the message including any attachments, without copying, using, or distributing any of the information contained therein. This e-mail message should not be interpreted to include a digital or electronic signature that can be used to authenticate an agreement, contract or other legal document, nor to reflect an intention to be bound to any legally-binding agreement or contract.] ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
