I agree with those who say that A and B are usually incompatible. If we're like chickens-in-a-barn-that-have-been-infected-with-bird-flu, the virus very rapidly becomes more virulent (hospital and care-home infections?). It's hard for a virus to infect your nose and throat quickly, and then stop.
In the medium term the herd will build up some immunity and then we'll become more like wandering albatrosses: the virus has to keep us on the move if it's going to get itself near another susceptible host. IMO the way a *respiratory *virus tries to "have its cake and eat it" - that is, get as much of both A and B as possible - is to develop thermal sensitivity. I.e. infect nose and throat but keep out of lungs and brain : https://www.preprints.org/manuscript/202101.0389/v1 Thanks, Patrick On Wed, Feb 17, 2021 at 9:46 PM Edwin Pozharski <pozharsk...@gmail.com> wrote: > I guess for such vehicle to be "extremely contagious" (or contagious at > all for that matter) it should be capable of rapidly multiplying inside the > host, so that it outruns immune system mediated destruction for at least > some time in order to be present in high enough concentration to > effectively spread via aerosols. Given the range of immunodeficiencies > present in any population, you are essentially guaranteed to kill at least > some people whose immune system will not be able to cope with rapidly > multiplying virus. You can theoretically fine tune the lethality of such > virus to make sure that number of people you thus murder will be less than > those that die either in no vaccine or traditional vaccination scenario, > but that would be ethical equivalent of that modern crypto fascist > suggestion that we just have to take it easy until herd immunity is > established, even though few million grandparents will die in the process > while the rest of us enjoy indoor dining. > > > > On Wed, Feb 17, 2021 at 12:33 PM Jacob Keller <jacobpkel...@gmail.com> > wrote: > >> It would seem to me that it should be possible to generate versions of >> the Covid virus that would: >> >> A. be extremely contagious and yet >> B. be clinically benign, and >> C. confer immunity to the original covid virus. >> >> If, then, this virus could be released, with appropriate "kill switch" >> safeguards built in, would this not solve the world's pandemic problems? Is >> there any reason, practically, why this approach would not be feasible? >> >> Maybe we don't really know enough to manipulate A, B, C yet? >> >> Or maybe it's too scary for primetime...nightmare bio-warfare apocalypse? >> >> Has this sort of thing been done, or does it have a name? >> >> Jacob >> -- >> >> +++++++++++++++++++++++++++++++++++++++++++++++++ >> >> Jacob Pearson Keller >> >> Assistant Professor >> >> Department of Pharmacology and Molecular Therapeutics >> >> Uniformed Services University >> >> 4301 Jones Bridge Road >> >> Bethesda MD 20814 >> >> jacob.kel...@usuhs.edu; jacobpkel...@gmail.com >> >> Cell: (301)592-7004 >> >> +++++++++++++++++++++++++++++++++++++++++++++++++ >> >> ------------------------------ >> >> To unsubscribe from the CCP4BB list, click the following link: >> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 >> > > ------------------------------ > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > -- patr...@douglas.co.uk Douglas Instruments Ltd. Douglas House, East Garston, Hungerford, Berkshire, RG17 7HD, UK Directors: Patrick Shaw Stewart, Peter Baldock, Stefan Kolek http://www.douglas.co.uk Tel: 44 (0) 148-864-9090 US toll-free 1-877-225-2034 Regd. England 2177994, VAT Reg. GB 480 7371 36 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
