There is a very old CCP4 program “sort water” which tries to do that, but I 
have no idea whether it still works :-(

see 
https://www.ccp4.ac.uk/html/sortwater.html

Phil

> On 13 Aug 2025, at 12:21, Firdous Tarique <[email protected]> wrote:
> 
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> --
> Hello everyone
> 
> I have a situation where the water molecules in my protein chains are not 
> named correctly. For example I want water molecules in protein Chain A to be 
> named as Chain A but few water molecules are named as chain B. As the water 
> numbers in hundreds it is difficult to do it manually. Is there a way where 
> water molecules near chain A (let's say within 3.5 A) are automatically 
> renamed as chain A ? 
> 
> Any help is appreciated
> 
> Best
> 
> Firdous
> 
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