In regards to alcoholism, the native peoples of the American content may have some genetic tendency towards this problem. I'm sorry I don't have a citation, but I saw a show that talked about a scientific study that indicates that these people may lack some genes for handling liquor. It does make some basic since. The natives of the Americas did not have alcohol technology before the arrival of Europeans, who have been making and consuming it for some 4000+ years. That does give them a few millennia head start on building up tolerance for the stuff.
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