Not sure if the product support team has a technote published on this yet or not, but check out this Microsoft KB article regarding IIS6 performance. This issue does affect ColdFusion MX 6.1 running on IIS6. Fortunately, it's a pretty simple tweak and ultimately it's going to be fixed by Microsoft in W2K3 service pack 1.
http://support.microsoft.com/default.aspx?scid=kb;EN-US;840875
BTW- make sure you have trusted cache turned on too.
Jim Schley
ColdFusion
Macromedia Inc.
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