I'm just going to echo a few things -

Timothy and I have talked at length about Clojure-like languages on other 
platforms.  His ideas and general approach have led to some very promising 
work (Pixie), and I can personally vouch for RPython as a platform.  My 
ideas led me to Terra ( http://terralang.org ) - which supports LLVM-based 
compilation (AOT and JIT), dynamic typing/programming via LuaJit 
integration, macros and AST manipulation, etc.  Based on this and some 
needs I was trying to fill, I produced cljs-terra ( 
https://github.com/ohpauleez/cljs-terra ).  The trade-off is the that 
library support is a mix of Lua and C libs all intertwined.

There is also the option of ClojureScript on top of Node.js (which I 
recently used for an IoT system) - which has an ecosystem of libraries.

All of that aside, I still tend to do my low-level work in C and C++14, 
with some Lua and Terra occasionally.  I also recently used Oracle's 
Embedded JVM with great success (producing a custom JRE for exactly what I 
needed).

Cheers,
Paul

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