Though my onc was 'encouraged' by my results, he stated he was not
happy I hadn't already reached 0%. His opinion of Gleevec is that
immediate and quick response means a better long term remission hold
and less to no chance of mutation, so he wished I had read 0% after 6
mths. After I heard this the rest of the information flew by me. I
need your help to interpret. My original tests stated 3% myeloblasts
& 85% Phil Chromosone translocation. # of Mataphases
counted/analyzed 20 Karyotyped 3. My new tests indicate 2%
myeloblasts, stating all cells analyzed had normal female karotype,
Phil Chromsone not observed & no other clonal chromosone changes
observed. Cells counted/analyzed 20, cells karyotyped 2. For the
BCR/ABL Test (FISH) # Pos Cells 2/544, % Pos Cells 0.4. I think
what's throwing me is the the BCR/ABL test, what is that telling
me?. My onc also said that he would re-test me in 4 mths & if I had
not reached 0% he wanted to combine Inteferon with my Gleevec and
that there would be worse side affects. Is anyone else been put on
this treatment? Dr. Awasthi (my onc) is not as encouraged with the
current treatments & trials but is happy to see remission levels
sticking for longer periods. He is currently on a team working
on 'individual' treatment typing, they are calling it the 'Bullet'.
He said basically they test and treat each individual patient and
customize the meds to that individual and they are targeting from a
different angle than the Gleevecs & BMS meds. Anyone heard of this?
He said it would probably be ready for trial in a year & would like
me to particpate. I love my doctor & I know he really is
knowledgable about CML but I'm not so sure what to think about all
this. Sorry about this being so long but I sure could use some
feedback/thoughts from my CML famliy.

Mind in major reeling mode,
Brenda
dx 5/04
gleevec 6/04
CCR 12/04 (???)
Mansfield, Tx.






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