Dear Germaine, As Trey has pointed out, what is the evidence of the second chromosomal abnormality? Is it that the 2 cells out of 20 cells that showed abnormality is not showing the Ph chromosome abnormality but another chromosomal abnormality? That would explain the difference between FISH and cytogenetics results. FISH is only looking for Ph chromosome, if it is not there in the cells tested, you will be negative. Cytogenetics looks at ALL chromosomes, so if there is a second chromosomal abnormality, this test is the only test that will pick it up. Does your cytogenetics report still say t(9;22), the Ph translocation? Please get a copy of the report and see. The 2 cells may not have the Ph chromosome, some other chromosomal abnormality.
What Trey says is very true, Sprycel is working well for you. Your FISH is negative (was it from the blood or marrow, blood FISH is not very reliable according to most docs) and your cytogenetics is at 10%. I have been in contact with quite a few Sprycel patients and they have had other chromosomal abnormalities with/without the phillies and these have disappeared over time for most on Sprycel. Please do get a copy of the report and let us know, the report should tell you what chromosomal abnormality you have and what is the percentage, whether this second abnormality is occurring with the Ph chromosome or not. I know two patients who had 9/10 transplants, neither survived, both had severe GVHD that became fatal. It is always best to have a 10/10 MUD match if you choose to do transplant. Let us know what it says on your cytogenetics report. I definitely think you should take, not one but maybe two or three medical opinions from top major CML centers before going for a BMT. Best Wishes, Anjana caregiver to Roy --~--~---------~--~----~------------~-------~--~----~ [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to CMLHope@googlegroups.com To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~----------~----~----~----~------~----~------~--~---
