My friend,
Hidroxyurea will only postpone the problem.
You should try any other drug. The injectable drug omacetaxine may achieve a
 durable response.

Check the site
http://www.mdanderson.org/newsroom/news-releases/2009/drug-shows-promise-for-t315i-mutated-chronic-myeloid-leukemia.html



On Fri, May 28, 2010 at 4:07 PM, Papu <pm.ru...@gmail.com> wrote:

> My mom (51 yrs) a case of CML with extra medullary relapse resulting
> in Neutizing Pyo-myositis of left calf requiring above knee
> amputation. Mutation analysis studies have shown T315i mutation which
> is known to be resistant to all available Tyrosine Kinase Inhibitor
> and she will require Allogenic Stem Cell Transplantation (HLA matched
> with younger brother).
>
> Recently she went into blast crisis (Blast cell= 23%), so my concern
> is should we try for promising drugs like HHT (Homoherringtonin) which
> seems to work in case of T315i mutation. She is now on hydroxyurea 2
> to 3gm per day. What are the other possible treatment options
> available ?
>
> --
> [CMLHope]
> A support group of http://cmlhope.com
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-- 
Ricardo

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