HI Choi,
This sounds very difficult. While your friend is not in molecular remission his blood work is stable..it has not spiked while on less sprycel. Is it possible he could go on 40 mgs or 40 five days a week and 60 two days a week? Sometimes just enough medication will keep the plural effusions at bay, while still keeping the cancer at bay as well. The risk is getting resistant, which he has already done with the Gleevec. But there are other options and another in trials that works in a different area than the other TKI's that is showing promise. So hopefully your friend can find the right med at the right dose to keep his disease in check. He may not tolerate full doses of the more recent and more potent meds..but there are several left to try. I can only tolerate 40 a day. Keeps me in check. I cannot go off med as I cannot take a high enough dose to get into that level of remission..but it works for me. Others who did not tolerate Sprycel have gone on bosutinib and it has worked for them... Take good care.. 18's hope and love, Beth -----Original Message----- From: Jamie Tufariello <gex6...@gmail.com> To: cmlhope <cmlhope@googlegroups.com> Sent: Thu, Jan 25, 2018 10:44 am Subject: Re: [CMLHope] off Sprycel On Tuesday, June 9, 2015, Choi <saehyun...@naver.com> wrote: Hi, this is Choi from South Korea. One of my CML friends had some problems and I just wonder who had a similar experience. He was diagnosed with CML chronic phase on july 2012 and started Gleevec 400mg for 16 months and switched to Sprycel due to E355G mutation. At that time his PCR was 1.89. He started Sprycel and E355G mutaiton was disappered. He was on Sprycel for 12 months. He developed pleural effusions after 12 months of Sprycel at that time his dose was 100mg. His doctor stopped Sprycel for 2 weeks and restarted Sprycel 80mg for 3 months. Once again he developed pleural effusions so he was off Sprycel for 4 weeks and restarted Sprycel 60mg until now and still had minor pleural effusions. PCR count was 0.37, 0.47, 0.45 and never drop to under 0.1% so his doctor was considering to switch to other drugs but hesitated to switch because of he had E355G mutation. Is there any one who had a similar experience? Choi. -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to CMLHope@googlegroups.com To unsubscribe from this group, send email to cmlhope-unsubscr...@googlegroups.com For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to cmlhope+unsubscr...@googlegroups.com. For more options, visit https://groups.google.com/d/optout. -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to CMLHope@googlegroups.com To unsubscribe from this group, send email to cmlhope-unsubscr...@googlegroups.com For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to cmlhope+unsubscr...@googlegroups.com. For more options, visit https://groups.google.com/d/optout. -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to CMLHope@googlegroups.com To unsubscribe from this group, send email to cmlhope-unsubscr...@googlegroups.com For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to cmlhope+unsubscr...@googlegroups.com. For more options, visit https://groups.google.com/d/optout.
