I had almost the exact treatment and drug changes.  I just went to the
Oncologist, Dr. Talpaz, U of M and he has taken me off the Sprycel and I am
now about to start on 100 mg of Bosulif.  Is there anyone else on Bosulif?
I would really like to know what I am about to be faced with.

On Thu, Jan 25, 2018 at 11:44 AM, Jamie Tufariello <gex6...@gmail.com>
wrote:

>
>
> On Tuesday, June 9, 2015, Choi <saehyun...@naver.com> wrote:
>
>> Hi, this is Choi from South Korea. One of my CML friends had some
>> problems and I just wonder who had a similar experience.
>>
>> He was diagnosed with CML chronic phase on july 2012 and started Gleevec
>> 400mg for 16 months and switched to Sprycel due to E355G mutation.
>> At that time his PCR was 1.89. He started Sprycel  and E355G mutaiton was
>> disappered. He was on Sprycel for 12 months.
>> He developed pleural effusions after 12 months of Sprycel at that time
>> his dose was 100mg. His doctor stopped Sprycel for 2 weeks and restarted
>> Sprycel 80mg for 3 months.
>> Once again he developed pleural effusions so he was off Sprycel for 4
>> weeks and restarted Sprycel 60mg until now and still had minor pleural
>> effusions.
>> PCR count was 0.37, 0.47, 0.45 and never drop to under 0.1% so his doctor
>> was considering to switch to other drugs but hesitated to switch because of
>> he had E355G mutation.
>> Is there any one who had a similar experience?
>>
>> Choi.
>>
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