Hi Alexis,
That's a relatively new mode. I don't know any software that handles
it. Are there any publically available examples of such files?

Marcin

On Fri, Oct 31, 2025 at 8:24 PM Alexis Rohou
<[email protected]> wrote:
>
> Hi Paul,
>
> Unless I'm mistaken, coot doesn't handle MRC maps in mode 12 (16-bit floats) 
> correctly. At least with coot-1.1.19 I couldn't get such a map to display, 
> but converting it to mode 2 (32-bit floats) and loading the converted map 
> works just as expected.
>
> If that's all correct, I would humbly request that support be added for mode 
> 12 MRC maps, which I work with very frequently.
>
> Cheers,
> Alexis
>
> --
> Alexis Rohou
> Distinguished Scientist
> Director of CryoEM
> Genentech, Department of Structural Biology
> 1 DNA Way
> South San Francisco, CA 94080
> Cell: 781 249 9629
> Pronouns: he/him/his
>
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