My latest project uses these styles (after having included normalize.css):

[snip]

html, body { background: #fff; }

html {
height: 100%;
overflow-y: scroll;
-webkit-text-size-adjust: 100%;
-ms-text-size-adjust: 100%;
}

body {
font: 100.01%/1.5 Cambria, Georgia, serif;;
color: #000;
-webkit-font-smoothing: antialiased;
       font-smoothing: antialiased;
text-rendering: optimizeLegibility;
min-height: 100%;
_height: 100%;
}

[/snip]

>From there, I'll calculate relative font sizes, margins/padding/other
on the base line-height.

OT, but I gained a lot of insight on font sizing and vertical rhythm
by studying web-based
base line grid techniques.
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