-Caveat Lector-

http://reason.com/rb/rb021202.shtml


Environmentalist Biofraud?

A new report challenges research published in the
respected journal, Nature.

Reason
By Ronald Bailey
February 12, 2002

"DNA Contamination Feared," declared the Washington
Post last fall. "Gene-altered DNA may be 'polluting'
corn," warned USA Today. Both papers�as well as many
other media outlets around the world--were reporting
the results of a scientific study published in the
prestigious journal Nature. Anti-biotech activists at
Greenpeace, Friends of the Earth, and the Union of
Concerned Scientists immediately seized on the results
to press for a ban on planting and exporting
genetically enhanced crops. It now appears that that
study's conclusions are completely bogus.

Last fall, Ignacio Chapela and David Quist, two
researchers from the University of California, claimed
that they had tested a number of samples of local
"creole" corn taken from farms located in remote areas
of Oaxaca, Mexico. They claimed that by using a very
sensitive genetic test called inverse polymerase chain
reaction (IPCR), they had found the cauliflower mosaic
virus 35S (CaMV35S) promoter in the local varieties of
corn. (Such local, noncommercial varieties are
sometimes known as "landraces.")

CaMV35S is regularly incorporated in many genetically
enhanced crops as a way to get the genes added by
biotechnologists (transgenes), such as those for
insect resistance, to express themselves.  The
Berkeley researchers suggested that perhaps native
Mexican corn varieties had by chance crossbred with
genetically enhanced varieties brought in from the
United States, despite a Mexican government ban since
1998 on planting bioengineered corn. Perhaps some
Mexican farmers had used corn imported for feed as
seed instead, they speculated. "The probability is
high that diversity is going to be crowded out by
these genetic bullies," asserted Chapela in USA Today.


Although Ignacio Chapela is an assistant professor of
microbiology at Berkeley, he is not exactly the model
of a dispassionate scientist. For example, in 1999
Chapela signed the "World Scientists' Statement
Calling for a Moratorium on GM Crops and Ban on
Patents," organized by a variety of anti-biotech
activist groups. The Statement called for a five-year
ban on planting all genetically enhanced crops and a
permanent ban on patenting crops, cell lines, and
genes. Chapela is also a board member of the activist
group Pesticide Action Network of North America, which
is also campaigning against plant biotechnology. In
other words, Chapela is a well-known anti-biotech
activist.

Two questions arise from the Nature study: Is it true?
And does it matter?

Earlier this year, the Center for the Improvement of
Maize and Wheat (CIMMYT) in Mexico (the research
center that launched the Green Revolution) checked its
extensive collections of corn and could find no
evidence that local varieties and bioengineered
varieties had crossbred. At the time CIMMYT released
the results of its analysis, its researchers had asked
Chapela for samples of his materials so that they
could check them, but he had not sent them.

Now a comprehensive review prepared for the editors of
the journal Transgenic Research, which will be
published in its February 2002 issue, finds that "no
credible scientific evidence is presented in the
[Chapela and Quist] paper to support claims made by
the authors that gene flow between transgenic maize
and traditional maize landraces has taken place." The
review finds, "It is most likely that the report by
Quist and Chapela is a testimony to technical failure
and artifacts which are common with PCR and IPCR."
Typically IPCR false positives occur because samples
can be easily contaminated with the material being
tested for.

Furthermore, according to the review, "most
frustrating" is that Chapela and Quist did not use
other, more reliable, techniques to determine the
presence of the transgenes.

The Transgenic Review article also soundly condemns
Nature for rushing to publish this flawed study. "What
is very surprising, however, is that a manuscript with
so many fundamental flaws was published in a
scientific journal that normally has very stringent
criteria for accepting manuscripts for publication�.It
is very disappointing that the editors of Nature did
not insist on a level of scientific evidence that
should have been easily accessible if the
interpretations were true. Consequently, no evidence
is presented to justify any of the conclusions
presented in the paper."

So are genetically enhanced varieties "genetic
bullies" that threaten corn biodiversity as Chapela
claims? Not at all.

"There is no scientific basis for believing that
out-crossing from biotech crops could endanger maize
biodiversity," said Luis Herrera-Estrella in a
statement issued in December. Herrera-Estrella is a
noted plant scientist and director of the Center for
Research and Advanced Studies in Irapuato, Mexico.
"Gene flow between commercial and native varieties is
a natural process that has been occurring for many
decades. Nor is there reason to believe that these
genes will become fixed into landraces unless farmers
select them for their increased productivity," added
Herrera-Estrella. "In the end, that would result in
improving the native varieties."

What's the bottom line? Chapela's "research" is
probably not a case of witting fraud, just another
activist "scientist" finding what he desperately
wanted to find. But the serious question is, Why did
the editors of one of the world's leading scientific
journals choose to abet him in his anti-biotech
campaign by publishing his sloppy work? One has to
wonder if perhaps their scientific judgments are being
clouded by their ideological concerns. The least the
editors of Nature can do now is withdraw the paper
formally with apologies to the scientific community.


Ronald Bailey is Reason's science correspondent and
the editor of Earth Report 2000: Revisiting the True
State of the Planet(McGraw-Hill)

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