My two cents... First, I think it depends on the organization!

I usually recommend, if most mailbox limits are going to be the same, going for 
a balanced/random distribution based on the mailbox profile and planned users 
per DB rather than another factor. And, if you have an entire department on one 
database, or senior staff - yes you can bring them online "first" in the event 
of a total loss of all database copies, but the opposite case is also true - 
you could end up in a situation with just your sales force or senior staff 
without email. If they are spread out, then at least you don't lose them all 
and a part of the organization isn't totally crippled. Also when it comes to 
sizing you are unlikely to have departments of identical size so you could end 
up with complicated sizing for LUNs that are hard to manage.

Of course not everyone wants a random distribution. Thinking of some customers 
over the last week I can give a couple of examples where that isn't the case..

Customer 1 - Has convention already in place, distributing by surname. Same 
mailbox limits for everyone in the organization, so analysed the surnames of 
the users who'll move onto these databases to determine the split of surnames 
per DB to tie up with the planned users per DB.

Customer 2 - Has different mailbox limits for different types of users, so 
mailbox database and log LUNs are sized to match these limits and user numbers, 
with balanced distribution across mailbox databases within each "tier".

Finally, looking at larger environments (100,000+) and going through some of 
the Exchange Environment Reports people have emailed me via the blog, there is 
a general tendency towards a combination of location (eg large, distributed 
environments) and then spreading the mailboxes across DBs rather than 
dedicating DBs to department/roles.

Steve

From: Shih, Henry [mailto:hms...@ci.livermore.ca.us]
Sent: 14 February 2012 17:30
To: MS-Exchange Admin Issues
Subject: Exchange 2010 database


What is the best practice or guideline when you create/organize databases in 
your organization? How do you add/organize users into different databases?

By location?

By their size of current mailbox?

By department?

By users' job title?

...............

Thanks.

Henry Shih
System Administrator

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