Actually, I have also been looking for cortical
thickness normative values. We have run our
first few research subjects with FreeSurfer (a
normal control and several patients with
neurodegenerative disorders), and I wanted to see
if the thickness values we're getting are in the
normal range. I have two papers: Salat et al.
(2004) and Fischl & Dale (2000) in Cerebral
Cortex. The Fischl and Dale gives average
thickness for gyral and sulcal regions. Am I
correct to guess that the average gyral and
sulcal regions are taken by averaging the
individual gyral and sulcal units from the
aparc.a2005s.stats files? The Salat et al.
article gives a global thickness measure--I was
wondering how I would calculate this?
Also, if thickness values are available for
individual parcellation units and/or whole lobes,
that would be very helpful as well. In
particular, the lobes would be helpful, as well
as ROIs most relevant for AD (e.g. entorhinal
cortex and temporal pole [Desikan et al., 2009]).
Thanks,
Dana
----------------------------------------------------------------------
Message: 1
Date: Wed, 13 May 2009 08:54:59 -0400 (EDT)
From: ra...@nmr.mgh.harvard.edu
Subject: Re: [Freesurfer] Literature values for cortical thickness
To: "Bruce Fischl" <fis...@nmr.mgh.harvard.edu>
Cc: freesurfer@nmr.mgh.harvard.edu, Falk L?sebrink
<falk.lu...@gmx.net>
Message-ID:
<49194.70.23.239.45.1242219299.squir...@mail.nmr.mgh.harvard.edu>
Content-Type: text/plain;charset=iso-8859-1
Hi Falk,
We do indeed have cortical thickness values for each of the parcellation
units for a range of subjects (healthly elderly, middle age and young
controls and Alzheimer's disease subjects). Which parcellation units are
you looking for? A whole lobe?
Best,
rahul
> Hi Falk,
>
> we published some values in our Cerebral Cortex paper , but I suspect the
> effective thickness will vary a bit as a function of pulse sequence, and
> certainly it will vary with things like age. Rahul has probably tabulated
> by parcellation unit if that helps.
>
> cheers
> Bruce
>
> On Wed, 13 May
> 2009, Falk Lüsebrink wrote:
>
>> Hi everyone,
>>
>>
>>
>> As I dont do a study in which I compare a group of subjects with some
>> kind
>> of abnormality with a control group I was looking for literature values
>> for
>> cortical thickness. The only paper I found which was written by von
>> Economo
>> et al. in 1925 doing a post-mortem analysis.
>>
>>
>>
>> Are there any more recent sources available which maybe even cover
>> in-vivo
>> values for regional cortical thickness? Actually Im looking for average
>> values across the whole lobes.
>>
>>
>>
>> Thanks in advance,
>>
>> Falk
>>
>>
------------------------------
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