Many will perform a map-based analysis on the cortical thickness or volume or area, then use a cluster-wise correction for multiple comparisons. If you want to go the ROI route, then you can test each ROI separately (ie, compute a p-value for the ROI0, then bonferoni correct the p-values for the number of tests (about 400). You could also FDR correct.
doug Liukarl wrote: > > Hello, Freesurfers > > After autorecon3, there are cortical measures for the over 30 > predefined regions. And for each regions, there are area, volume, and > thickness 3 different measures, which means there are approximately > 200 measure for both hemispheres. > > As a preliminary analysis without specific priori hypothesis, what is > the standard way to examine the massive data to find possible group > difference for a small sample size about 40 subjects with 20 in each > group. > > thanks > > Karl > > > 搜索本应是彩色的,快来体验新一代搜索引擎-必应,精美图片每天换哦! 立即试 > 用！ <http://cn.bing.com/?form=CRMADS%20> > ------------------------------------------------------------------------ > > _______________________________________________ > Freesurfer mailing list > Freesurfer@nmr.mgh.harvard.edu > https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer -- Douglas N. Greve, Ph.D. MGH-NMR Center gr...@nmr.mgh.harvard.edu Phone Number: 617-724-2358 Fax: 617-726-7422 Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting FileDrop: www.nmr.mgh.harvard.edu/facility/filedrop/index.html _______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
