Hi Allison,

A suggestion is to use the surface area of each hemisphere as the 
weighting factor. The global average thickness for both hemispheres is 
then given by:

bh.thickness = (lh.thickness*lh.surfarea + rh.thickness*rh.surfarea) / 
(lh.surfarea + rh.surfarea).

If you use the data in the ?h.aparc.stats, it already discounts the 
'unknown' region, so you don't have to worry about that.

All the best,

Anderson


On 08/14/2011 06:12 PM, Allison R. Kaup wrote:
> Hi all,
>
> Please pardon the novice question...   but what is the best way to get
> global mean cortical thickness (i.e. combined across hemispheres)?  I
> have used mris_anatomical_stats to get mean thickness separately for
> each hemisphere.   To get a global mean thickness, would I just take a
> simple average (RH mean thickness + LH mean thickness)/2?  Or, do I
> need some sort of weighted average to account for hemispheric size
> diffferences?  If so, what would I use as the weight?
>
>
> Thanks!
> Allison
>
>
>

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