A side note: If you are using FS 4.5.0 or earlier, there is also BrainSegVolNotVent, which discount ventricles. If you want to capture effects of aging or atrophy, perhaps this could be more sensitive than BrainSegVol.

On 24/08/11 12:32, Anderson Winkler wrote:
Hi Zuzana,

Yes, you can use BrainSegVol as a measurement of brain volume (I'd assume you are using FS <=4.5.0). Note that there is another measurement that you might be interested in, the IntraCranialVol. These measurements tell different things and not necessarily correlate well one with another depending on the sample. BSV considers the voxels labelled as GM and WM, including subcortical structures and cerebellum and so, it correlates better with amount of GM and WM and tends to be more sensitive to pathology, atrophy and aging. ICV is more robust to these effects. You may want to choose the one that is more appropriate to your study.

Also, if you are considering brain volume as a covariate for cortical thickness, it's not necessary. Thickness correlates poorly with brain volume, and these two things are not correlated genetically.

Hope this helps!

All the best,

Anderson


On 24/08/11 05:39, zuzana nedelska wrote:
Hello,

I have a question about calculating brain volume (in mm3) when performing recon-all. Do I take brainseg volume in the analysis stream line as subject's brain volume (in mm3)?

Thank you for reply.


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