Dear freesurfer experts,

I'm using Qdec and I want to control for age (a continuous variable) and sex 
(f,m or 1,0).

Do I need to center age (i.e., subtract the score from its mean) before I 
select it as a nuisance factor?
Do I need to center sex?

I found that selecting age_centered as a nuisance factor vs. selecting 
age_uncentered as a nuisance factor led to very different results… not sure 
what is the correct way to go.
In brief, if I want to control for age and sex, which of the following is the 
correct way to go?

  1.  Center neither age nor sex (f,m). Then choose age_uncentered as a 
nuisance factor, but sex_uncentered as a discrete/fixed factor.
  2.  Center age but not sex (f,m). Then choose age_centered as a nuisance 
factor, but sex_uncentered as a discrete/fixed factor.
  3.  Center age but not sex (1,0). Then choose both age_centered and 
sex_uncentered as nuisance factors.
  4.  Center age and sex (1,0). Then choose both age_centered and sex_centered 
as nuisance factors.

Thanks in advance!
Daniel
--
Yung-Jui "Daniel" Yang, PhD
Postdoctoral Researcher
Yale Child Study Center
New Haven, CT
(203) 737-5454
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